Browsing by Author "Dhumal, Bhagyashree R"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
Item Stability Indicating Method for the Determination of Mefenamic Acid in Pharmaceutical Formulations by HPLC.(2014-12) Dhumal, Bhagyashree R; Bhusari, Kishore P; Tajne, Madhukar R; Ghante, Mahavir H; Jain, Nishant SA simple, RP-HPLC stability indicating method was developed for determination of mefenamic acid in pharmaceutical formulations and its degradation products using C8 column with the mobile phase containing mixture of Buffer : Acetonitrile + THF in the ratio of 55:45 v/v at a flow rate of 1.0 ml/min was found to yield satisfactory retention time of about 18.253 min with sharp symmetrical peak at a detection wavelength of 285 nm. The method was validated using ICH guidelines and was found to be linear in the range 0.5-2 μg/ mL. The proposed method shows good separation of mefenamic acid and its degradation products. The developed method can be applied successfully for the determination of mefenamic acid and its degraded products.