Browsing by Author "Areekul, S"
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Item 131 -I-fibrinogen metabolism and fibrinolytic activity in Plasmodium falciparum malaria.(1971-12-01) Areekul, S; Kanakakorn, K; Kasemsuth, R; Boonyananta, C; Matrakul, DItem Abnormally elevated serum transcobalamin II levels in patients with cerebral malaria.(1994-12-01) Areekul, S; Churdchu, K; Thanomsak, W; Cheeramakara, C; Wilairatana, P; Charoenlarp, PTranscobalamin II (TCII) levels have been reported to be elevated in patients with many clinical conditions including proliferative reticuloendothelial system. As reactive macrophage hyperplasia frequently occurs in patients with malaria, the objective of the present study was to determine TCII in patients with Plasmodium falciparum with cerebral symptoms. The studies were performed on 14 cerebral malaria patients as well as 60 normal subjects. The mean values of serum vitamin B12 and TCII levels were significantly higher in the patient group and 6 and 7 patients had serum vitamin B12 and TCII levels higher than the normal values. There was direct relationship between serum TCII levels and BUN or creatinine levels. These findings indicated that raised serum TCII level occurred only in patients with renal insufficiency. A decreased glomerular fiLtration rate reduced the amount of vitamin B12 and TCII-B12 that filtered through the glomeruli resulting in the reduced proximal tubular cells uptake and its degradation of TCII. This reduced lysosomal enzyme activity, therefore, prolongs the intravascular TCII survival and increased secretion of TCII into the circulation. Therefore, serum TCII levels were elevated in these cerebral malaria patients.Item Acetylcholinesterase activities in cerebrospinal fluid of patients with Plasmodium falciparum cerebral malaria.(1985-09-01) Areekul, S; Churdchu, K; Yamarat, PSerum cholinesterase (CHE) and acetylcholinesterase (ACHE) in cerebrospinal fluid (CSF) were determined simultaneously in 30 patients with P. falciparum cerebral malaria. Nineteen patients (63%) had low serum CHE and mean value of this serum enzyme in 30 patients was significantly lower than that of non-infected group. CSF ACHE levels were found to be significantly lower than those of normal subjects reported earlier. Post-treatment in the hospital for one week, both serum CHE and CSF ACHE levels in 9 convalescent subjects increased significantly. These findings indicated that both serum CHE and CSF ACHE levels were depressed in patients with cerebral malaria and increased on recovery.Item Acetylcholinesterase activity in different stages of Ancylostoma caninum.(1982-06-01) Areekul, S; Cheeramakara, CItem Acetylcholinesterase activity in red cells infected with Plasmodium falciparum culture in vitro.(1983-06-01) Areekul, S; Sucharit, P; Cheeramakara, C; Siripanth, CItem Alteration of serum protein concentrations in pregnancy.(1977-09-01) Areekul, S; Rostreichert, IItem Alteration of the liver blood flow and phagocytic activity of the reticuloendothelial system in monkeys infected with Plasmodium knowlesi.(1973-12-01) Areekul, S; Matrakul, D; Chantachum, Y; Kasemsuth, RItem Alterations in capillary permeability in rhesus monkeys with Plasmodium knowlesi infection.(1985-06-01) Areekul, SThe transcapillary escape rate and capillary permeability to albumin were studied in 3 rhesus monkeys throughout the whole course of P. knowlesi infection. The transcapillary escape rates started to increase on the first week after infection and were significantly higher than the control values during infection. Plasma volume was found to be increased while plasma albumin concentration decreased which resulted in the increased intravascular mass, outflux and clearance of albumin from the intravascular to the extravascular compartments. Increased As/delta X and Ps during malarial infection indicated that the increased capillary permeability was due to increased capillary surface area and the increased endothelial permeability. As there was no relationship between increased plasma volume or intravascular mass of albumin and As/delta X or Ps, the increased capillary permeability in these infected monkeys could not be explained by the stretching pore phenomena. As these parameters show a close relationship to the parasitemia, therefore malarial parasites may play a role in causing increased capillary permeability.Item Alterations in the viscosity and deformability of red cells in patients with Plasmodium falciparum.(1988-04-01) Areekul, S; Yamarat, PItem Apparent viscosity of blood flowing in isolated rabbit ear.(1970-04-01) Areekul, SItem Application of radioisotopes in the study of malaria in Thailand.(1979-04-01) Areekul, SItem Ascorbic acid and iron excretion in a thalassemic child.(1983-06-01) Hathirat, P; Areekul, S; Pleehachinda, R; Tuntawiroon, MItem Biology and food habits of the snail-killing fly, Sepedon plumbella Wiedemann (Sciomyzidae: Diptera).(1973-09-01) Bhuangprakone, S; Areekul, SItem Bleeding diathesis in malaria.(1979-09-01) Areekul, SItem Blood volume, red cell volume and plasma volume in patients with hookworm infection.(1974-06-01) Areekul, SItem A case of pernicious anemia due to vitamin B12 deficiency.(1991-09-01) Insiripong, S; Tulayalak, P; Areekul, SItem Catalase activity in red cell and liver of mice infected with Plasmodium berghei.(1986-03-01) Areekul, S; Boonme, YHydrogen peroxide (H2O2) has been incriminated to have an oxidative killing malaria parasite. As P. berghei-infected mouse red cells generated H2O2 in vivo, this would result in the alteration of catalase status of the host. The present study was undertaken to determine catalase activity in red cells and liver of mice infected with P. berghei. The studies were performed in 17 samples of infected red cells as well as 20 samples of the normal red cells. Results showed that the catalase activity in red cells of the infected group was significantly lower (p less than 0.01) than that of the normal group. There was a reverse relationship between catalase activity and parasitemia. Crude parasite lysates possessed no catalase activity. Liver catalase content in the infected group was also found to be significantly lower (p less than 0.05) than that of the control group. All these findings indicated that P. berghei-infected mice caused a depressed catalase activity in red cells and liver which was possibly due to the catalatic function in detoxifying the increased H2O2 to water and free oxygen.Item Cholinesterase activity after treatment with mebendazole, thiabendazole and metronidazole in patients with various parasitic diseases.(1982-12-01) Areekul, S; Viravan, C; Churdchu, K; CheermaKara, CItem Cholinesterase activity in human blood.(1981-08-01) Areekul, SItem Coagulation and fibrinolysis in malaria.(1972-07-01) Areekul, S