Browsing by Author "Ali, Hapipah Mohd"

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    Effect of Bis [benzyl N'-(indol-3-ylmethylene)-hydrazinecarbodithioato]-zinc(II) derivatives on wound healing in Sprague Dawley rats.
    (2011-01) Mughrabi, Fathi Farag; Hashim, Harita; Ameen, Mahmood; Khaledi, Hamid; Ali, Hapipah Mohd; Ismail, Salmah
    Effects of topical application of Bis[benzyl N'-(indol-3-ylmethylene)-hydrazinecarbodithioato]-zinc(II) (BHCZ) on wound healing and histology of healed wound were assessed. Sprague Dawley rats were experimentally induced wound in the posterior neck area. Tween 20 (0.2 ml of 10%) was applied to rats in Group 1 (negative control). Intrasite gel (0.2 ml) was applied topically to rats in Group 2 as reference. BHCZ at the concentrations 0.2 ml of 25, 50 and 100 mg/ml were applied to Group 3, 4 and 5, respectively. Wound dressed with BHCZ significantly healed earlier than those treated with 10% Tween 20. Also wound dressed with 100 mg/ml BHCZ accelerated the rate of wound healing compared to those dressed with intrasite gel and, 25 mg/ml and 50 mg/ml BHCZ. Histological analysis of healed wound with BHCZ showed comparatively less scar width at wound enclosure and the healed wound contained less macrophages and large amount of collagen with angiogenesis compared to wounds dressed with 10% Tween 20. Results of this study showed that wounds dressed with 100 mg/ml of BHCZ significantly enhanced acceleration of the rate of wound healing enclosure, and histology of healed wounds showed comparatively less macrophages and more collagen with angiogenesis.
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    Synthesis, characterization, and biological applications of some 2-acetylpyridine and acetophenone derivatives.
    (2012-12) Gwaram, Nura Suleiman; Ali, Hapipah Mohd; Saharin, Siti Munirah; Abdulla, Mahmood Ameen; Hassandarvish, Pouya; Lin, Thong Kwai; Ching, Chai Lay; Ooi, Cher Lin
    This paper comprises two series of complexes which showed different modes of coordination. The fist series involved an N,N’,N”-donor Schiff base ligand from the reaction of 2-acetylpridine as carbonyl compound with N,N’-dimethylethylenediamine (L1), the second series involved N,N’,O-donor Schiff base from the condensation reaction of 2-hydroxyacetophenone (ketone) as carbonyl compound with N,N’-dimethylethylenediamine (L2). The ligands and complexes were characterized by using melting point, elemental analysis, FT-IR, NMR, and UV/Visible spectroscopy. The complexes showed very low cytotoxicity towards MCF-7 breast cancer cell line. They also showed moderate zone inhibition against Gram positive bacterium Methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii and Pseudomonas aeruginosa. No antimicrobial activity observed with Klebsiella pneumonia.