Synthesis, characterization, and biological applications of some 2-acetylpyridine and acetophenone derivatives.
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Date
2012-12
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Abstract
This paper comprises two series of complexes which showed different modes of coordination. The fist series
involved an N,N’,N”-donor Schiff base ligand from the reaction of 2-acetylpridine as carbonyl compound with
N,N’-dimethylethylenediamine (L1), the second series involved N,N’,O-donor Schiff base from the condensation
reaction of 2-hydroxyacetophenone (ketone) as carbonyl compound with N,N’-dimethylethylenediamine (L2).
The ligands and complexes were characterized by using melting point, elemental analysis, FT-IR, NMR, and
UV/Visible spectroscopy. The complexes showed very low cytotoxicity towards MCF-7 breast cancer cell line.
They also showed moderate zone inhibition against Gram positive bacterium Methicillin-resistant
Staphylococcus aureus, Acinetobacter baumannii and Pseudomonas aeruginosa. No antimicrobial activity
observed with Klebsiella pneumonia.
Description
Keywords
Schiff bases, Complexes, Anticancer, MCF-7, Antibacterial, MRSA
Citation
Gwaram Nura Suleiman, Ali Hapipah Mohd, Saharin Siti Munirah, Abdulla Mahmood Ameen, Hassandarvish Pouya, Lin Thong Kwai, Ching Chai Lay, Ooi Cher Lin. Synthesis, characterization, and biological applications of some 2-acetylpyridine and acetophenone derivatives. Journal of Applied Pharmaceutical Science. 2012 Dec; 2(12): 27-38.