Browsing by Author "Agarwal, S S"
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Item Abnormal erythrocyte membrane phospholipid organisation in chronic myeloid leukaemia.(1987-03) Kumar, A; Daniel, S; Agarwal, S S; Gupta, C MThe membrane phospholipid organisation in the red cells of humans suffering from chronic myeloid leukaemia has been analysed using the amino-group labelling reagent trinitrobenzenesulphonic acid and the fluid-sensing fluorophore, Merocyanine 540. Unlike the normal human erythrocytes, trinitrobenzenesulphonic acid in intact chronic myeloid leukaemia erythrocytes modified about 30% phosphatidylserine, under controlled conditions. Also, the chronic myeloid laukaemia red cells, but not the normal cells, were found to bind the fluorescent dye Merocyanine 540. These results demonstrate that loss of the transmembrane phospholipid asymmetry in chronic myeloid leukaemia erythrocytes is accompanied by an enhancement in the outer surface fluidity and, therefore, suggest that the red cells membrane phase-state asymmetry originates probably from the asymmetric arrangements of phospholipids across the membrane bilayer.Item Acromesomelic dwarfism: report of a family with two affected siblings.(1997-12-26) Danda, S; Phadke, S R; Agarwal, S SItem Adverse drug reactions in hospitalized patients.(1983-06-01) Doval, D C; Nath, C; Gulati, A; Agarwal, S S; Bhargava, K PItem Adverse effects of genetic counselling on women carriers of disease: the Indian perspective.(2001-01-13) Phadke, S R; Agarwal, S SItem Alpha-1 antitrypsin deficiency in pulmonary diseases.(1974-11-01) Agarwal, S S; Tandon, V K; Farooqui, J Z; Misra, R NItem Antenatal diagnosis of genetic disorders.(1974-01-01) Agarwal, S SItem Antibodies to Entamoeba histolytica in patients with rheumatoid arthritis.(1985-07-01) Singh, I P; Das, S K; Sharma, P; Dutta, G P; Agarwal, S SItem Anticonvulsant activity of the mixed fatty acids of Elaeocarpus ganitrus roxb. (Rudraksh).(1984-07-01) Dasgupta, A; Agarwal, S S; Basu, D KItem Bacteriological examination of diarrhoeal stools in infants and children in Jaipur (Rajasthan).(1976-06-01) Naruka, B S; Sharma, U; Saxena, S; Agarwal, S S; Sharma, M LItem Biological behaviour of moderate dysplasia--a prospective study.(1996-03-01) Murthy, N S; Sardana, S; Narang, N; Agarwal, S S; Sharma, S; Das, D KThe present communication reports the biological behaviour of women with moderate dysplastic lesions of uterine cervix based on a long term prospective study. Two hundred and thirty nine women with moderate dysplasia by cervical cytology who satisfied the criteria for registration were longitudinally followed up at 3 +/- 1 monthly intervals along with age and parity matched controls for a period ranging from 4 to 132 months. The cumulative rate of progression from moderate dysplasia to malignancy (CIS) was observed to be 23.0% at the end of 72 months of follow up with mean transition interval of 24.2 months. Out of 239 cases, 142 women who had more than 24 months of follow up were considered for studying the biological behaviour of the lesion. It was observed that during a follow up of 132 months, 14(9.9%) and 15(10.6%) women progressed to carcinoma in-situ and severe dysplasia respectively. The persistence of lesion was observed in 21(14.8%) women while 11(7.3%) and 81(57.0%) regressed to mild dysplasia and normalcy respectively.Item Blood groups in malignant diseases.(1965-12-16) Tyagi, S P; Pradhan, S; Agarwal, S SItem Cellular immune response to retinal S-antigen & interphotoreceptor retinoid binding protein fragments in idiopathic human uveitis.(1996-04-01) Rajasingh, J; Singh, V K; Singh, V; Sharma, K; Agarwal, S SThe role of retinal antigens in idiopathic human uveitis has been studied in 38 patients of uveitis, and 30 patients of systemic connective tissue disease (CTD) and 30 healthy volunteers. Lymphocyte proliferative responses were tested in vitro against native S-antigen, its uveitopathogenic peptides (peptide M, peptide G), yeast histone H3 peptide and uveitopathogenic fragment of interphotoreceptor retinoid binding protein (IRBP: R16) to establish their role in pathogenesis of human uveitis. Seven patients with uveitis, and none among CTD patients and healthy volunteers, responded (stimulation index > 3) to at least one retinal antigen used. One uveitis patient showed response to native S-antigen, peptide M and yeast histone H3. One responded to both S-antigen and peptide M and another responded to both peptide G and R16 peptide. Two responded to S-antigen only, one to peptide M and one to peptide G. In addition, one uveitis patient responded to yeast histone H3 only. These results suggest that retinal antigens may play a role in the etiopathogenesis of a subset of idiopathic human uveitis.Item Characterization of beta-thalassaemia mutations in 57 beta-thalassaemia families seen at Lucknow.(1994-09-01) Agarwal, S; Naveed, M; Gupta, U R; Kishore, P; Agarwal, S SAs an initial step towards establishing prenatal diagnostic service for beta-thalassaemia in the state of Uttar Pradesh, we have investigated the prevalence of five common mutations reported from India in 57 families, each with an index patient of thalassaemia major, by amplification refractory mutation system (ARMS). Thirtyone of the 57 families (54.3%) hailed from Uttar Pradesh; 11 (19.3%) from Sindh in Pakistan, 6 (10.5%) from Punjab, 6 (10.5%) from North-West Pakistan and one each (1.8%) from Bengal, Madhya Pradesh and Bihar. In the 31 families from Uttar Pradesh, 29 were of beta-thalassaemia and 2 of HbE/beta-thalassaemia. IVS-1 nt 5 (G-C) mutation was the most common mutation in families native to Uttar Pradesh. This mutation was identified in 60 per cent (33 out of 55) of the obligate heterozygotes. Amongst the 43 obligate heterozygote carriers originating from Western India, the prevalence of IVS-1 nt 5 (G-C) mutation was 46.5 per cent; 619 bp deletion 23.3 per cent; Co 8/9 (+G) mutation 11.6 per cent and Co 41/42 (-CTTT) mutation 4.6 per cent. In 23.6 per cent of carriers from Uttar Pradesh and 7.0 per cent of carriers from Western India, none of the 5 mutations tested were detected. IVS-1 nt 1 (G-T) mutation was found in one family native to Sindh.Item Clinical profile of hereditary spherocytosis in North India.(2002-11-14) Panigrahi, I; Phadke, S R; Agarwal, A; Gambhir, S; Agarwal, S SAIMS OF THE STUDY: Hereditary spherocytosis (HS) is a familial hemolytic disorder manifesting as anaemia, recurrent jaundice, splenomegaly with marked heterogeneity in clinical presentation. The objective was to study the clinical spectrum of the disorder in India. METHODOLOGY: We studied 50 HS patients and followed them for up to six years (Age range 2-47 years). RESULTS: The presenting features were jaundice 35 out of 50, anaemia 30 out of 50 (requiring blood transfusion in 25). Splenomegaly was found in all patients. Increased osmotic fragility was found in all patients whereas spherocytes were found in only 19 out of 42 patients. Reduced red cell survival was noted in 9/12 patients studied with 51Cr labeled RBCs. There was a definite improvement in the hemoglobin values in those who underwent splenectomy. Thirteen cases had similarly affected family member/s. Fifteen of the cases had family history consistent with autosomal dominant (AD) inheritance (eight families) while in six cases (5 families), inheritance was likely to be autosomal recessive (AR). There was intrafamilial variability in the age of presentation in the AD families. CONCLUSIONS: Our results suggest that both autosomal dominant and recessive patterns of HS are seen in India and the clinical profile of the Indian HS patients is similar to that described in other populations. HS presenting in childhood is also not uncommon. However, the predominant underlying protein defect in Indian patients needs to be characterized.Item Clinical trial of ethyl acetate extract of gum gugulu (gugulipid) in primary hyperlipidemia.(1986-04-01) Gopal, K; Saran, R K; Nityanand, S; Gupta, P P; Hasan, M; Das, S K; Sinha, N; Agarwal, S SItem Clinical trial of gugulipid--a new hypolipidemic agent of plant origin in primary hyperlipidemia.(1986-12-01) Agarwal, R C; Singh, S P; Saran, R K; Das, S K; Sinha, N; Asthana, O P; Gupta, P P; Nityanand, S; Dhawan, B N; Agarwal, S SItem Clinicopathological profile of lymphomas in India.(1992-05-01) Aziz, S A; Agrawal, S S; Agarwal, S SItem Comparative evaluation of Plasmodium knowlesi and P. cynomolgi antigens in the indirect fluorescent antibody test for human malaria.(1983-05-01) Agarwal, S S; Nath, A; Sharma, P; Srivastava, I K; Dwivedi, S R; Dutta, G PItem Comparative trials of phototherapy versus photobarb in the management of neonatal hyperbilirubinaemia.(1976-01-01) Agarwal, S S; Misra, P K; Upadhyay, U K; Bajpai, P CItem Copper containing intrauterine devices and cervical carcinogenesis--48 months follow up.(1980-11-01) Luthra, U K; Mitra, A B; Prabhakar, A K; Bhatnagar, P; Agarwal, S S