Journal of Pharmaceutical Research International

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https://imsear.searo.who.int/handle/123456789/151207

Chief Editors: Prof. Ke-He Ruan, Prof. Alyautdin Renad N and Dr. Ali Nokhodchi
ISSN: 2456-9119

Frequency: Quarterly

Language: English

Open Access Peer-reviewed journal

Web site: https://www.journaljpri.com/index.php/JPRI

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Browsing Journal of Pharmaceutical Research International by Author "Abbas, Afshan"

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    Impact of Foeniculum vulgare Fortified Diet on Coagulation Profile and Some Biochemical Parameters
    (SCIENCEDOMAIN international, 2020-06) Abbas, Afshan; Ikram, Rahila; Hasan, Faiza; Bukhari, Qurrat Ul Ain; Sarfaraz, Sana; Adil, Abeer
    Aims:Coagulation profile shows the clotting ability of blood. Biochemical tests indicate health status of vital organs such as liver, heart and kidneys. Herbal products are being assessed for their role in affecting these parameters. We evaluated role of Foeniculumvulgareincorporated diet on coagulation profile and some important biochemical parameters.Study Design:Laboratory centred randomized controlled trial.Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018 Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculumvulgareand 4% Foeniculumvulgaregroup. Control group was given standard diet whereas; 2% and 4% Foeniculumvulgaregroups were maintained on standard diet containing 2% and 4% Foeniculumvulgarecrushed seeds. Coagulation profile and some biochemical parameters were done after interval of a month, for two months.Results:Platelet count and fibrinogen increased while activated partial thromboplastin time (APTT) levels decreased in both the study groups animals as compared to control, while blood urea nitrogen (BUN), creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) elevation was noted both Foeniculumvulgaregroups but within normal range.Conclusion:Foeniculumvulgaremay have some role in affecting coagulation and biochemical profile These parameters, however, need clinical trial to validate reliability
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    Protective Role of Foeniculum vulgare Mill. in Brain Disorders; A New Window
    (SCIENCEDOMAIN international, 2020-08) Abbas, Afshan; Ikram, Rahila; Iftikhar, Saadia; Bukhari, Qurrat ul Ain; Nisar, Uzair; Adil, Abeer
    Aims: Alzheimer disease and epilepsy are two of the central nervous system (CNS) disorders that not only affect the quality of life of patients but also of family members and caretakers. Remedies for these illnesses are available in allopathic medicines but not without side effects. Herbal products are being investigated for these ailments. Protective role of Foeniculum vulgareMill. was assessed in this study. Study Design:Laboratory based randomized controlled trial. Place and Duration of Study: Conducted inPharmacology Department of University of Karachi, between March 2018 and April 2018 Methodology:Mice and rats were divided in three groups, control, 2% and 4% F. vulgaregroups, each containing 10 rodents. Control group was fed standard rodent diet, whereas, study groups were given 2% and 4% F. vulgareseeds (crushed) incorporated in standard rodent diet. Epilepsy model was made for mice and Alzheimer disease study was done using rats and passive avoidance test.Results:Lower incidence of seizures and mortality in both study groups as compared to control in epilepsy model and memory retaining effect in both treated groups in Alzheimer disease model was recorded with statistical significance. Conclusion:Clinical studies should be conducted to validate the protective role of this herb in these disorders