Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study.
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Date
2013-07
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Abstract
Background: Hypothyroidism is associated with many biochemical abnormalities including
increased serum creatinine and uric acid levels. Many studies were done abroad regarding
serum creatinine and uric acid levels in hypothyroid patients. We designed this study in our
population for evaluation of serum creatinine and uric acid levels in hypothyroid patients.
Objective: To assess serum creatinine and uric acid levels in hypothyroid patients and to find
out relationship of creatinine and uric acid levels with severity of hypothyroidism. Materials
and Methods: This retrospective cross sectional study to evaluate the serum creatinine and
uric acid levels of hypothyroid patients and to find out relationship of hyperuricemia and
hypercreatininemia with severity of hypothyroidism was done in the department of
Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka. Results were compared
with that of age and sex matched healthy euthyroid controls. Statistical analyses were
performed by using SPSS for Windows version 10.0. ANOVA and unpaired ‘t’ tests were done
to see the significance among the groups and between groups respectively. Pearson’s
correlation coefficient test was done to see the correlation of serum creatinine and uric acid
levels with the severity of hypothyroidism. Results: Mean serum creatinine and uric acid
levels in cases were 1.38 ± 0.53 and 7.00 ± 2.54 mg/dL respectively compared to 1.01 ± 0.17
and 5.21 ± 1.35 mg/dL in controls. Conclusion: Mean serum creatinine and uric acid levels
were found significantly higher in hypothyroid patients compared to controls. These findings
suggest that hyperuricemia and hypercreatininemia are associated with hypothyroidism.
Therefore, patients presenting with these biochemical abnormalities are recommended to be
investigated to explore hypothyroidism.
Description
Keywords
Hypothyroidism, Creatinine, Uric acid, Hyperuricemia
Citation
Khan Md. Aminul Haque, Majumder Md. Ishaque, Hoque Md. Mozammel, Fariduddin Md., Mollah Forhadul Hoque, Arslan Iqbal. Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study. Journal of Enam Medical College. 2013 Jul; 3(2): 84-87.