Lead Associated Nephrotoxicity: A Global Concern

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dc.contributor.authorThakur, Ajiten_US
dc.contributor.authorJuyal, Deepaken_US
dc.contributor.authorSayana, Ashutoshen_US
dc.contributor.authorThaledi, Shwetaen_US
dc.contributor.authorBatra, Jyotien_US
dc.date.accessioned2019-12-06T09:24:04Z
dc.date.available2019-12-06T09:24:04Z
dc.date.issued2018-11
dc.description.abstractAmongst toxic heavy metals, lead ranks as one of the most serious environmental poisons all over the world. An occupational and environmental exposure to lead remains a serious problem in many developing and industrializing countries, as well as in some developed countries. Lead exposure can be detrimental to every organ in the human body with kidney and brain being predominantly susceptible to its deleterious effects. An association between lead poisoning and renal diseases in humans has been recognized and documented by several studies. Excessive exposure to lead may cause acute or chronic nephrotoxic effects. Studies suggest that prolonged lead exposure may be an overlooked risk factor for chronic kidney disease. Majority of lead associated renal toxicity are a result of the previous chronic exposure, ongoing chronic exposure or current high acute exposure to lead. Both glomerular and tubular effects have been reported. Glomerular effects range from high molecular weight proteinuria to a nephritic syndrome whereas tubular changes consist of an enhanced urinary excretion of enzymes. Lead poisoning and associated nephrotoxicity is an important and preventable health problem that remains to be fully addressed. However due to lack of education regarding the dangers of working with lead or lead containing products, potential health hazards of lead poisoning still exist and are rising in India. The regulatory bodies should be more vigilant and make it mandatory to evaluate and create awareness among the workers as well as general population about the lead toxicity and should insist on regular health checkups to prevent adverse health effects.en_US
dc.identifier.affiliationsAssistant Professor, Department of Biochemistry, Jaipur National University Institute of Medical Sciences & Research, Jaipur – 302017, Rajasthan.en_US
dc.identifier.affiliationsAssistant Professor, Department of Microbiology, Govt. Doon Medical College, Patelnagar, Dehradun – 248001, Uttarakhand.en_US
dc.identifier.affiliationsProfessor & Head, Department of Surgery, Govt. Doon Medical College, Patelnagar, Dehradun, Uttarakhand – 248001.en_US
dc.identifier.affiliationsTutor, Department of Microbiology, Sridev Suman Subharti Medical College, Subhartipuram, Prem Nagar, Dehradun - 248007, Uttarakhand.en_US
dc.identifier.affiliationsProfessor, Department of Biochemistry, Santosh Medical College, Gaziabad, NCR, Delhi, India.en_US
dc.identifier.citationThakur Ajit, Juyal Deepak, Sayana Ashutosh, Thaledi Shweta, Batra Jyoti. Effect of Maturity And Birth Weight On Umbilical Cord Blood Lipid Profile: A Fetal Programming Phenomenon. Annals of International medical and Dental Research. 2018 Nov; 4(11): 1-4en_US
dc.identifier.issn2395-2822
dc.identifier.issn2395-2814
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/188394
dc.languageenen_US
dc.publisherSociety for Health Care & Research Developmenten_US
dc.relation.issuenumber11en_US
dc.relation.volume4en_US
dc.source.urihttps://doi.org/10.21276/aimdr.2018.4.6.BC1en_US
dc.titleLead Associated Nephrotoxicity: A Global Concernen_US
dc.typeJournal Articleen_US
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