Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy

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dc.contributor.authorSreedharanen_US
dc.contributor.authorKalpana, Devadathanen_US
dc.contributor.authorPA, Mohammed Kunjuen_US
dc.contributor.authorBindusha, Sasidharanen_US
dc.contributor.authorJayakumar, Parameswaran Pillaien_US
dc.contributor.authorMinikumari, Amma Vasumathy Ammaen_US
dc.contributor.authorSaboorabeegum, MuthuBeevien_US
dc.date.accessioned2020-04-23T07:42:33Z
dc.date.available2020-04-23T07:42:33Z
dc.date.issued2018-04
dc.description.abstractObjective: To assess the effect of monotherapy withCarbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH vitamin D levels in children with epilepsy compared tocontrols.Design: Cross-sectional study.Setting: Outpatient department of a tertiary-care PediatricNeurology centre, and a nearby day-care centre and school.Study period: June 2012 to May 2013Participants: Children with epilepsy aged 2 to 13 years onmonotherapy with CBZ (n=28) or VPA (n=28) for at least 6months; 109 age-matched controls from a nearby day-care centreand school.Results: The median (IQR) values of 25 (OH) vitamin D was 18.0ng/mL (13.7-27.3), 21.35 ng/mL (16.4 -25.2) and 30.5 ng/mL(19.1-43.7) in CBZ, VPA and control group, respectively (P=0.008). 60.7% of patients in CBZ group and 35.7 % in VPA grouphad low 25 (OH) D levels (<20 ng/mL) compared to 27.8% incontrols (P=0.001).The serum alkaline phosphatase level washigher in children on carbamazepine therapy (P=0.001) thancontrols.Conclusion: This study identifies significant risk of vitamin Ddeficiency in ambulant children with epilepsy on monotherapy withCBZ or VPA.en_US
dc.identifier.affiliationsDepartments of Pediatric Neurology, Medical College, Thiruvananthapuram, India.en_US
dc.identifier.affiliationsPediatrics, Medical College, Thiruvananthapuram, India.en_US
dc.identifier.affiliationsBiochemistry; Government Medical College, Thiruvananthapuram, India.en_US
dc.identifier.citationSreedharan, Kalpana Devadathan, PA Mohammed Kunju, Bindusha Sasidharan, Jayakumar Parameswaran Pillai, Minikumari Amma Vasumathy Amma, Saboorabeegum MuthuBeevi. Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy. Indian Pediatrics. 2018 Apr; 55(4): 307-310en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199063
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber4en_US
dc.relation.volume55en_US
dc.source.urihttps://www.indianpediatrics.net/apr2018/307.pdfen_US
dc.subjectAdverse effect; Antiepileptic drugs; Hypovitaminosis Den_US
dc.titleVitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapyen_US
dc.typeJournal Articleen_US
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