Comparison of the protective efficacy on mekongi schistosomiasis in mice induced by antigens derived from cercariae, schistosomulae and adult worms.

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dc.contributor.authorUsawattanakul, Wen_US
dc.contributor.authorKitikoon, Ven_US
dc.contributor.authorChaicumpa, Wen_US
dc.contributor.authorJanecharut, Ten_US
dc.contributor.authorWongwit, Wen_US
dc.contributor.authorPattara-Arechachai, Jen_US
dc.contributor.authorTharavanij, Sen_US
dc.date.accessioned2009-05-27T17:05:28Z
dc.date.available2009-05-27T17:05:28Z
dc.date.issued1993-06-01en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractProtective efficacy of the extracts of cercariae, schistosomulae and adult worms of S. mekongi was studied in mice receiving immunizations with these extracts emulsified with Freund's complete adjuvant initially and incomplete adjuvant subsequently, and compared with mice receiving physiological saline with or without adjuvants as controls. After challenge with cercariae, the animals were sacrificed and the larvae or adult worms harvested by lung recovery and perfusion techniques on day 5 and weeks 6-8, respectively. Worm reduction rates were significantly higher in mice receiving extracts of schistosomula (59%) and adult worms (51%) than in those receiving the cercarial extracts (31%). Similar findings were obtained with the perfusion technique showing worm reduction rates of 57%, 53% and 30% in mice receiving extracts of schistosomulae, adult worms and cercariae, respectively. ELISA antibody titers were correspondingly increased in mice receiving extracts of schistosomulae and adult worms, but not in those receiving cercariae. This apparent association may be inadequate to suggest that the increase in ELISA titer be used as an indicator for resistance in mekongi schistosomiasis.en_US
dc.description.affiliationDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationUsawattanakul W, Kitikoon V, Chaicumpa W, Janecharut T, Wongwit W, Pattara-Arechachai J, Tharavanij S. Comparison of the protective efficacy on mekongi schistosomiasis in mice induced by antigens derived from cercariae, schistosomulae and adult worms. Asian Pacific Journal of Allergy and Immunology. 1993 Jun; 11(1): 71-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36431
dc.language.isoengen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Helminth --biosynthesisen_US
dc.subject.meshAntigens, Helminth --immunologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshFreund's Adjuvanten_US
dc.subject.meshImmunizationen_US
dc.subject.meshMiceen_US
dc.subject.meshSchistosoma --chemistryen_US
dc.subject.meshSchistosomiasis --immunologyen_US
dc.titleComparison of the protective efficacy on mekongi schistosomiasis in mice induced by antigens derived from cercariae, schistosomulae and adult worms.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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