Risk Assessment of the Growth Inhibitor Bonzi with the Active Substance Paclobutrazol

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dc.contributor.authorSverdrup, L. E.en_US
dc.contributor.authorBjørge, C.en_US
dc.contributor.authorEklo, O. M.en_US
dc.contributor.authorGrung, M.en_US
dc.contributor.authorKällqvist, T.en_US
dc.contributor.authorKlingen, I.en_US
dc.contributor.authorLåg, M.en_US
dc.contributor.authorRopstad, E.en_US
dc.contributor.authorØvrebø, S.en_US
dc.date.accessioned2023-07-14T08:08:13Z
dc.date.available2023-07-14T08:08:13Z
dc.date.issued2022-10
dc.description.abstractBonzi is a new plant growth regulator containing the active ingredient paclobutrazol of the triazole chemical class. Bonzi is for use on ornamental plants, such as Chrysanthemum, Perennial Plants, Bedding Plants, Foliage Plants, Geraniums, Hibiscus and Azaleas, in nurseries and greenhouses. VKM was requested by the Norwegian Food Safety Authority to consider the potential of Bonzi and paclobutrazol to induce reproductive effects in humans; in particular the relative sensitivity and relation between maternal effects and the effects on the offspring; and to what extent cleft palate observed in developmental studies in rat can be regarded as a specific teratogenic effect of relevance for humans. The risk assessment was finalized in a meeting in VKM’s Scientific Panel on Plant Protection Products on May 24. 2013. VKM’s conclusions are as follows: No adverse effect on fertility or reproductive performance was seen in rats. VKM concluded that the incidences of twisted snout observed in the F1 and F2 offspring of paclobutrazol treated rats are not likely to represent a developmental alteration, but rather an unspecific toxic effect. Marked maternal toxicity was seen in rats above 250 mg/kg bw/day, while partially ossified 7th cervical transverse processes and supernumerary 14th ribs were found in the offspring at 10 - 40 mg/kg/day. VKM concluded that the latter should be regarded as a direct teratogenic effect of paclobutrazol. Furthermore, VKM concluded that the data from the developmental toxicity studies are inconclusive regarding the effect on cleft palate development in rat foetuses. VKM proposes a NOAEL of 2.5 mg/kg bw/day for paclobutrazol based on a developmental toxicity study in rats.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Det Norske Veritas, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian Enviroment Agency, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian Institute of Bioeconomy Research, Norwayen_US
dc.identifier.affiliationsUniversity of Oslo / Norwegian Scientific Committee for Food Safety (VKM), Norwegian Institute for Water Research, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM),Norwegian Institute of Public Health (FHI), Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian University of Life Sciences, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), National Institute of Occupational Health, Norwayen_US
dc.identifier.citationSverdrup L. E., Bjørge C., Eklo O. M., Grung M., Källqvist T., Klingen I., Låg M., Ropstad E., Øvrebø S.. Risk Assessment of the Growth Inhibitor Bonzi with the Active Substance Paclobutrazol. European Journal of Nutrition & Food Safety. 2022 Oct; 14(10): 7-8en_US
dc.identifier.issn2347-5641
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219612
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber10en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.9734/ejnfs/2022/v14i1030532en_US
dc.subjectVKMen_US
dc.subjectassessmenten_US
dc.subjectNorwegian Scientific Committee for Food Safetyen_US
dc.subjectBonzi.en_US
dc.titleRisk Assessment of the Growth Inhibitor Bonzi with the Active Substance Paclobutrazolen_US
dc.typeJournal Articleen_US
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