Efficacy of prophylactic ondansetron in Thai patients undergoing gastrointestinal tract surgery.

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dc.contributor.authorLekprasert, Ven_US
dc.contributor.authorMeesangnil, Sen_US
dc.contributor.authorPausawasdi, Sen_US
dc.contributor.authorPongravee, Ven_US
dc.date.accessioned2009-05-27T21:26:00Z
dc.date.available2009-05-27T21:26:00Z
dc.date.issued1996-06-01en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractPostoperative nausea and vomiting (PONV) although frequently is considered a minor postoperative complication, it may be greatly trouble some especially in ambulatory surgical patients. This study was performed to compare the efficacy and safety of a single intravenous bolus dose of ondansetron 4 mg with the placebo in the prevention of PONV and to assess the safety and tolerability in Thai patients. By using the randomized, double-blind, placebo controlled study design, we enrolled 82 Thai male and female patients, ASA physical status I or II, between the ages of 12 and 75 year undergoing gastrointestinal tract surgery with general anesthesia in the study. A single intravenous bolus dose of ondansetron 4 mg or a single dose of placebo was administered immediately prior to the induction of the anesthesia. The patients were followed for 24 hours to assess PONV and adverse events. We found that intravenous ondansetron 4 mg seemed to be effective and safe in the prevention of PONV especially in female patients (P = 0.037) based on clinical observation. However there was no statistical significance between groups. None of the patients in both groups had any adverse events. In addition, there was no significant difference between preoperative and postoperative abnormalities of liver enzymes. Also we had found no difference in patient satisfaction between two groups.en_US
dc.description.affiliationDepartment of Anesthesia, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationLekprasert V, Meesangnil S, Pausawasdi S, Pongravee V. Efficacy of prophylactic ondansetron in Thai patients undergoing gastrointestinal tract surgery. Journal of the Medical Association of Thailand. 1996 Jun; 79(6): 382-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44780
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntiemetics --administration & dosageen_US
dc.subject.meshChilden_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Diseases --surgeryen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNausea --epidemiologyen_US
dc.subject.meshOndansetron --administration & dosageen_US
dc.subject.meshPostoperative Perioden_US
dc.subject.meshThailanden_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVomiting --epidemiologyen_US
dc.titleEfficacy of prophylactic ondansetron in Thai patients undergoing gastrointestinal tract surgery.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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