Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer's Disease

Simple item page
dc.contributor.authorShekhar, Shashanken_US
dc.contributor.authorTripathi, Manjarien_US
dc.contributor.authorDey, A.B.en_US
dc.contributor.authorDey, Sharmisthaen_US
dc.date.accessioned2023-07-21T11:27:57Z
dc.date.available2023-07-21T11:27:57Z
dc.date.issued2022-01
dc.description.abstractObjectives:The aim of this study was to evaluate the serum RE1 silencing transcription factor (REST) level in Alzheimer's disease (AD), mild cognitive impairment (MCI), and elderly controls by using surface plasmon resonance (SPR) technology. Materials and Methods?In this case–control study of 133 subjects, 49 patients with AD, 49 patients with MCI, and 35 elderly controls were recruited. The REST protein concentrations were evaluated by SPR. The resonance unit for each sample was recorded and the concentration of serum REST of study group was derived from the standard curve. All the experiments were done in triplicates. Statistical analysis was done and p-value of < 0.05 was considered as statistically significant. Results?A significant difference was observed in the Montreal Cognitive Assessment score, Hindi Mental State Examination scale (HMSE) score education, disease duration, and gender among the groups. A significant (p>0.0001) difference in the duration of disease between AD and MCI was observed. It was observed that the mean concentration of serum REST was not significantly (p?=?0.266) different among the groups. Conclusion?This study first time evaluated the serum levels of REST in AD, MCI and age-matched elderly controls. The rest levels were similar in all groups; however, it can provide a new direction to future blood-based biomarker studies of REST.en_US
dc.identifier.affiliationsDepartment of Biophysics, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Geriatric Medicine, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Geriatric Medicine, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationShekhar, Shashanken_US
dc.identifier.citationTripathi, Manjarien_US
dc.identifier.citationDey, A.B.en_US
dc.identifier.citationDey, Sharmistha. Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer's Disease. Annals of the National Academy of Medical Sciences. 2022 Jan; 58(1): 22-26en_US
dc.identifier.issn0379-038X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/220201
dc.languageenen_US
dc.publisherThieme Medical and Scientific Publishers Pvt. Ltden_US
dc.relation.issuenumber1en_US
dc.relation.volume58en_US
dc.source.urihttps://doi.org/10.1055/s-0041-1731970en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectserum RE1 silencing transcription factoren_US
dc.subjectmild cognitive impairmenten_US
dc.subjectsurface plasmon resonanceen_US
dc.titleExploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer's Diseaseen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ANAMS2022v58n1p22.pdf
Size:
535.46 KB
Format:
Adobe Portable Document Format
Download
Collections
Annals of the National Academy of Medical Sciences (India)