DNA base excision repair genes variants rs25487 (X-ray repair cross-complementing 1) and rs1052133 (human 8-oxoguanine glycosylase 1) with susceptibility to ovarian cancer in the population of the Jammu region, India

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dc.contributor.authorVerma, Sonalien_US
dc.contributor.authorSharma, Varunen_US
dc.contributor.authorNagpal, Ashnaen_US
dc.contributor.authorBhat, Amritaen_US
dc.contributor.authorBhat, GRen_US
dc.contributor.authorShah, Ruchien_US
dc.contributor.authorWakhloo, Ajayen_US
dc.contributor.authorSuri, Jyotsnaen_US
dc.contributor.authorAbrol, Deepaken_US
dc.contributor.authorKaul, Sandeepen_US
dc.contributor.authorBhat, Audeshen_US
dc.contributor.authorVerma, Vijeshwaren_US
dc.contributor.authorKumar, Rakeshen_US
dc.date.accessioned2020-11-18T10:07:29Z
dc.date.available2020-11-18T10:07:29Z
dc.date.issued2019-12
dc.description.abstractBackground: Ovarian cancer is highly prevalent in the population of Jammu, in India; the ovarian cancer ranks third among other types of cancer prevalent in females. However, association studies on ovarian cancer are lacking in this region. We aimed to investigate the disease susceptible variants rs1052133 (human 8-oxoguanine glycosylase 1 [hOGG1]) and rs25487 (X-ray repair cross-complementing 1 [XRCC1]) with ovarian cancer in population of Jammu, India. Materials and Methods: The study conducted in the Shri Mata Vaishno Devi University is a 3-year study which included a total of 280 well-characterized samples (130 ovarian cancer cases and 150 healthy controls). hOGG1 and XRCC1 polymorphisms were determined by polymerase chain reaction-based restriction fragment length polymorphism, and these genotyping results were confirmed by Sanger sequencing. Hardy–Weinberg equilibrium for both single-nucleotide polymorphisms (SNPs) was assessed using the Chi-square test. The allele and genotype-specific risks were estimated by odds ratios with 95% confidence intervals. Results: In this preliminary study, SNP rs1052133 showed protection with ovarian cancer (P = 0.042). The SNP rs25487 was not found associated with ovarian cancer (P = 0.271). Conclusion: Our results indicate that the G allele of rs1052133 imparts protection to the population whereas variant rs25487 was not associated with ovarian cancer in population from the Jammu region, indicating that larger sample size is needed for further statistical validation. Further, association of other SNPs in these genes should also be carried out as their role cannot be ruled out.en_US
dc.identifier.affiliationsSchool of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsSchool of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsSchool of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsSchool of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsSchool of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Government Medical College, Jammu, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Government Medical College, Jammu, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDepartment of Radiotherapy, Government Medical College, Jammu, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsShri Mata Vaishno Devi Narayana Superspeciality Hospital, Katra, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsCentre for Molecular Biology, Central University, Jammu, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsSchool of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsSchool of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, Indiaen_US
dc.identifier.citationVerma Sonali, Sharma Varun, Nagpal Ashna, Bhat Amrita, Bhat GR, Shah Ruchi, Wakhloo Ajay, Suri Jyotsna, Abrol Deepak, Kaul Sandeep, Bhat Audesh, Verma Vijeshwar, Kumar Rakesh. DNA base excision repair genes variants rs25487 (X-ray repair cross-complementing 1) and rs1052133 (human 8-oxoguanine glycosylase 1) with susceptibility to ovarian cancer in the population of the Jammu region, India. Journal of Cancer Research and Therapeutics. 2019 Oct; 15(5): 1270-1275en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213521
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber5en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_65_18en_US
dc.subjectHuman 8‑oxoguanine DNA N‑glycosylase 1en_US
dc.subjectrestriction fragment length polymorphismen_US
dc.subjectX‑ray repair cross‑complementing 1en_US
dc.titleDNA base excision repair genes variants rs25487 (X-ray repair cross-complementing 1) and rs1052133 (human 8-oxoguanine glycosylase 1) with susceptibility to ovarian cancer in the population of the Jammu region, Indiaen_US
dc.typeJournal Articleen_US
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