Pediatric disorders of sex development.

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dc.contributor.authorKulkarni, Ketan Prasad
dc.contributor.authorPanigrahi, Inusha
dc.contributor.authorDas, Reena
dc.contributor.authorKaur, Surinder
dc.contributor.authorMarwaha, Ram Kumar
dc.date.accessioned2012-10-23T06:26:09Z
dc.date.available2012-10-23T06:26:09Z
dc.date.issued2009-09
dc.description.abstractThe management of disorders of sexual differentiation (DSD) involves a multidisciplinary approach. The main aim of analysis was to study the phenotype-karyotype correlation in North Indian children with DSD. The records of pediatric DSD were retrieved and characteristics noted. Of total of 58 children, 43 (74.1%) and 10 (17.2%) were raised as males and females respectively. The mean age at presentation was 31.3±9 months. The karyotype was 46XY in 45 (77.6%) and 46XX in 12 (20.7%). CAH was commonest cause of DSD (36.2%), followed by gonadal dysgenesis. Of the 15 patients of 46 XY CAH, there were 5 with 17-α hydroxylase deficiency, 2 with 3-β HSD deficiency and one case of lipoid adrenal hyperplasia. There was an excess of genetic males, possibly due to prevalent socio-cultural factors and gender bias favoring males. There is a need to improve the diagnostic facilities and incorporate a team approach in management of DSD.en_US
dc.identifier.citationKulkarni Ketan Prasad, Panigrahi Inusha, Das Reena, Kaur Surinder, Marwaha Ram Kumar. Pediatric disorders of sex development. Indian Journal of Pediatrics. 2009 Sept; 76(9): 956-958.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142381
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/icb/t09/i9/icbt09i9p956.pdfen_US
dc.subjectAmbiguous genitaliaen_US
dc.subjectChildrenen_US
dc.subjectHypospadiasen_US
dc.subjectKaryotypeen_US
dc.subjectPhenotypeen_US
dc.subject.meshChi-Square Distribution
dc.subject.meshChild, Preschool
dc.subject.meshDisorders of Sex Development --diagnosis
dc.subject.meshDisorders of Sex Development --epidemiology
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndia --epidemiology
dc.subject.meshInfant
dc.subject.meshKaryotyping
dc.subject.meshMale
dc.subject.meshPhenotype
dc.titlePediatric disorders of sex development.en_US
dc.typeArticleen_US
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