Hemolytic disease of newborn caused by multiple Rh antibodies

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dc.contributor.authorRoutray, Suman Sudhaen_US
dc.contributor.authorBehera, Rachitaen_US
dc.contributor.authorSahoo, Jagdish Prasaden_US
dc.contributor.authorAcharya, Devi Prasaden_US
dc.contributor.authorPati, Bibudhenduen_US
dc.date.accessioned2020-09-24T07:45:54Z
dc.date.available2020-09-24T07:45:54Z
dc.date.issued2019-11
dc.description.abstractHemolytic disease of Fetus and Newborn (HDFN) usually results due to natural occurring antibodies or alloimmunization in mother but the presence of multiple red cell antibodies increases the risk of development of significant HDFN. Here author reported a case of hemolytic disease of fetus and newborn in a preterm baby caused by multiple maternal antibodies. Direct Antiglobulin Test (DAT) on neonate blood sample was positive (3+) with monospecific DAT showed IgG type which was confirmed by heat elution. Antibody identification of eluate was done using commercial 11-cell panel by gel method showing specificity to anti-D and anti-C antibody which was differentiated from anti-G by sequential adsorption and elution studies. Neonate was treated with double volume exchange transfusion (DVET) using leucoreduced, irradiated O Rh D and C negative PRBC suspended in AB plasma and discharged 6th day in a stable condition. So, all pregnant women should be at least advised for ICT irrespective of Rh D negative status. If ICT is positive, they should be referred to higher center for proper Immunohematological work up, so that proper blood unit for DVET could be identified.en_US
dc.identifier.affiliationsDepartment of Transfusion Medicine, IMS and SUM Hospital, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Neonatology, IMS and SUM Hospital, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.citationRoutray Suman Sudha, Behera Rachita, Sahoo Jagdish Prasad, Acharya Devi Prasad, Pati Bibudhendu. Hemolytic disease of newborn caused by multiple Rh antibodies. International Journal of Contemporary Pediatrics. 2019 Nov; 6(6): 2688-2691en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204363
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20194755en_US
dc.subjectAlloimmunizationen_US
dc.subjectAnti-Cen_US
dc.subjectAnti-Den_US
dc.subjectAntibody identificationen_US
dc.subjectHeat Elutionen_US
dc.subjectSequential adsorptionen_US
dc.titleHemolytic disease of newborn caused by multiple Rh antibodiesen_US
dc.typeJournal Articleen_US
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