Microvascular Density of Invasive Breast Carcinoma as an Independent Prognostic Factor in Comparison with Already Established Ones : A Study from Northeast India
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Date
2024-12
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THE INDIAN MEDICAL ASSOCIATION
Abstract
Background and Objectives : Breast Carcinoma is the most common cancer in women Worldwide. This study was done to assess the tumour angiogenesis using CD34 immuno-reactivity and thereby see the relationship of the same with already established prognostic factors like age, histological type, tumour size, tumour grade (Modified Bloom Richardson Scoring System) and lymph nodal metastasis. Materials and Methods : The 19 Breast Carcinoma cases included in this study were diagnosed in the Department of Pathology, Gauhati Medical College and Hospital within 1 year and Tumour Angiogenesis was assessed using CD34 immunoreactivity. The results were then compared with the already established prognostic factors. Results : The relationship of MVD/HPF with tumour size, MBR tumour grade and lymph nodal metastases was found to be statistically significant at p-value <0.05. MVD/HPF with patient age was not statistically significant. Grade I &II IDC and medullary carcinoma had low MVD/HPF, whereas grade III IDC, metaplastic carcinoma and invasive papillary carcinoma had high MVD/HPF. Conclusion : Tumour angiogenesis assessed by MVD/HPF following CD34 immunostaining can be used as a prognostic factor in Breast Carcinoma alongwith other known factors with more studies and standardized methods to calculate the MVD/HPF and can also be a potential targeted therapy with anti-angiogenic factors.
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Keywords
Tumour Angiogenesis, Breast Carcinoma, Prognostic Factor
Citation
Devi Junu, Suhana Asreen . Microvascular Density of Invasive Breast Carcinoma as an Independent Prognostic Factor in Comparison with Already Established Ones : A Study from Northeast India. Journal of the Indian Medical Association. 2024 Dec; 122(12): 44-46