Effect of nifedipine and amlodipine on wound healing in rats.

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dc.contributor.authorBhaskar, H Nen_US
dc.contributor.authorUdupa, Saraswathi Len_US
dc.contributor.authorUdupa, A Laxminarayanaen_US
dc.date.accessioned2004-01-24en_US
dc.date.accessioned2009-06-01T07:08:22Z
dc.date.available2004-01-24en_US
dc.date.available2009-06-01T07:08:22Z
dc.date.issued2004-01-24en_US
dc.description.abstractThe wound healing effect of two calcium channel blockers, nifedipine and amlodipine was studied in rats using incision and excision wound models. In incision wound, two straight paravertebral skin thickness incision were made and on tenth day skin tensile strength was measured by using continuous water flow technique. In excision wound, circular piece of skin excised in its full thickness and wound contraction monitored by alternate day wound tracing and epithelisation period was monitored by noting the number of days required for escher to fall. Drugs enhanced the skin tensile strength in incision wound model. In excision wound model, wound contraction is increased on 4th and 16th day but epithlisation period was not significantly altered. In conclusion, calcium channel blockers can be used to enhance wound healing, especially if wound healing was suppressed by steroids.en_US
dc.description.affiliationDepartment of Pharmacology, Kasturba Medical College, Manipal--576 019.en_US
dc.identifier.citationBhaskar HN, Udupa SL, Udupa AL. Effect of nifedipine and amlodipine on wound healing in rats. Indian Journal of Physiology and Pharmacology. 2004 Jan; 48(1): 111-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107925
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAmlodipine --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium Channel Blockers --pharmacologyen_US
dc.subject.meshDexamethasone --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucocorticoids --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNifedipine --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSkin Physiological Phenomenaen_US
dc.subject.meshTensile Strengthen_US
dc.subject.meshWound Healing --drug effectsen_US
dc.titleEffect of nifedipine and amlodipine on wound healing in rats.en_US
dc.typeJournal Articleen_US
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