Bioactive potential of bacterial endosymbionts isolated from Lamellodysidea herbacea, marine sponge from the coast of South Andaman, India, against human bacterial pathogens

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dc.contributor.authorSawhney, Snehaen_US
dc.contributor.authorMishra, Jayant Kumaren_US
dc.date.accessioned2020-10-16T08:55:57Z
dc.date.available2020-10-16T08:55:57Z
dc.date.issued2019-04
dc.description.abstractSponge diversity along the coasts of Andaman and Nicobar Islands comprises about 126 species and sponges are knownto act as a host to endosymbionts, which is found to possess novel antimicrobial metabolites. In the present study,screening and characterization of antibiotic producing endosymbiotic bacteria from the marine sponge Lamellodysideaherbacea were investigated. Eight isolated bacterial strains from the sponge were screened for bioactivity againsthuman pathogens Escherichia coli (MTCC 443), Bacillus cereus (MTCC 430), Bacillus subtilis (MTCC 121), Listeriamonocytogenes (MTCC 839), Staphylococcus aureus (MTCC 3160) and Salmonella enterica typhimurium (MTCC1252) and only two strains CAB1 and CAB38 exhibited activity. Ethyl acetate extracted metabolites of strain CAB1showed significant activity against four pathogens B. cereus, B. subtilis, S. aureus and S. entrica typhimurium andCAB38 against three pathogens B. subtilis, E. coli and S. entrica typhimurium. The 16S rRNA gene sequence of thesetwo strains showed 99% sequence similarity with known sequences in the GenBank and their phylogenetic analysisconfirmed strain CAB1 as Bacillus amyloliquefaciens (MK135790) and CAB38 as Alcaligenes faecalis (MK135791).The study demonstrated that metabolites from sponge associated bacterial endosymbionts can be a major source ofunique compounds with potential bioactivity.en_US
dc.identifier.affiliationsDepartment of Ocean Studies and Marine Biology, Pondicherry University, Port Blair, Andaman & Nicobar Islands, India.en_US
dc.identifier.citationSawhney Sneha, Mishra Jayant Kumar. Bioactive potential of bacterial endosymbionts isolated from Lamellodysidea herbacea, marine sponge from the coast of South Andaman, India, against human bacterial pathogens. Journal of Applied Pharmaceutical Science. 2019 Apr; 2019 Apr: 001-008en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210556
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.90301en_US
dc.subjectAndaman Seaen_US
dc.subjectbioactive metabolitesen_US
dc.subjectendosymbiotic bacteriaen_US
dc.subjectL. herbacea.en_US
dc.titleBioactive potential of bacterial endosymbionts isolated from Lamellodysidea herbacea, marine sponge from the coast of South Andaman, India, against human bacterial pathogensen_US
dc.typeJournal Articleen_US
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