Antinociceptive, anti-inflammatory and antipyretic effects of ethanolic root bark extract of Icacina senegalensis in rodents.

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dc.contributor.authorDavid-Oku, Esien
dc.contributor.authorAkuodor, Godwin Christian
dc.contributor.authorEdet, Emmanuel Effiong
dc.contributor.authorOgbuji, Godknows K
dc.contributor.authorObiajunwa-Otteh, Juliet Ifeoma
dc.contributor.authorAja, Daniel Ogbonna John
dc.date.accessioned2016-09-05T05:38:45Z
dc.date.available2016-09-05T05:38:45Z
dc.date.issued2016-02
dc.description.abstractTo investigate the ethanolic root bark extract of Icacina senegalensis for antinociceptive, anti-inflammatory and antipyretic activities in rats and mice. Acetic acid-induced abdominal constriction and tail immersion tests were used to evaluate the antinociceptive activity of the extract. Egg albumin and carrageenan-induced paw oedema were used to study the anti-inflammatory activity, whereas the anti-pyretic studies were evaluated on yeast and amphetamine-induced pyrexia. The root bark extract (50, 100 and 200 mg/kg) significantly (P<0.05) showed inhibitory activity for all the models in the antinociceptive, anti-inflammatory and antipyretic assayed. Result shows that ethanolic root bark extract of Icacina senegalensis possesses phytochemicals with therapeutic potential against painful, inflammatory and feverish conditions, and thus explain the use of Icacina senegalensis for similar ailments in traditional medicine.en_US
dc.identifier.citationDavid-Oku Esien, Akuodor Godwin Christian, Edet Emmanuel Effiong, Ogbuji Godknows K, Obiajunwa-Otteh Juliet Ifeoma, Aja Daniel Ogbonna John. Antinociceptive, anti-inflammatory and antipyretic effects of ethanolic root bark extract of Icacina senegalensis in rodents. Journal of Applied Pharmaceutical Science. 2016 Feb; 6(2): 104-108.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/176918
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/abstract.php?article_id=1781en_US
dc.subjectIcacina senegalensisen_US
dc.subjectrooten_US
dc.subjectpainen_US
dc.subjectinflammationen_US
dc.subjectfeveren_US
dc.subjectratsen_US
dc.subjectmiceen_US
dc.titleAntinociceptive, anti-inflammatory and antipyretic effects of ethanolic root bark extract of Icacina senegalensis in rodents.en_US
dc.typeArticleen_US
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