Senescence in oral lichen planus as assessed by the immunohistochemical evaluation of senescence marker protein-30 (Regucalcin)

Simple item page
dc.contributor.authorPeter, CDen_US
dc.contributor.authorShashidara, Ren_US
dc.contributor.authorJain, Ven_US
dc.contributor.authorHaragannavar, VCen_US
dc.contributor.authorSamuel, Pen_US
dc.contributor.authorNayak, SR.en_US
dc.date.accessioned2023-08-10T07:33:14Z
dc.date.available2023-08-10T07:33:14Z
dc.date.issued2023-03
dc.description.abstractBackground: Oral lichen planus is a T-cell-mediated chronic inflammatory disease affecting approximately 1% to 2% of the population, the etiology of which is currently unknown. The objectives of this study were to observe if senescence occurs in oral lichen planus, through the assessment of the immunohistochemical expression of a novel marker for senescence called Senescence marker protein-30 or regucalcin, and compare the expression to that in oral lichenoid reaction and non-specific inflammation. Subjects and Methods: The study material consisted of 30 cases of oral lichen planus, 15 cases of oral lichenoid reaction and 15 cases of non-specific inflammation. The number of positive cells in ten randomly selected high power fields were counted in the epithelium and the connective tissue separately and the mean was determined. Results: Mann–Whitney U test was used to statistically analyze if there was any significant difference in the expression of Senescence marker protein-30 between oral lichen planus, oral lichenoid reaction and non-specific inflammation. Even though a greater expression was seen in the oral lichen planus cases than oral lichenoid reaction, the difference in both the epithelium and connective tissue was not statistically significant. Conclusion: This study shows that in addition to the already known mechanisms like apoptosis and increased cell proliferation rates, the activated T-lymphocytes may also trigger a senescent change in the cells of oral lichen planus. As with the other mechanisms, this is also seen only in a small proportion of the cases.en_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Educare Institute of Dental Sciences, College Road, Kiliyamannil Campus, Chattiparamba, Malappuram, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Coorg Institute of Dental Sciences, Kodagu, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Public Health Dentistry, KLE Society's Institute of Dental Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, M.S Ramaiah University of Applied Sciences, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Prosthodontics, Educare Institute of Dental Sciences, Malappuram, Kerala, Indiaen_US
dc.identifier.citationPeter CD, Shashidara R, Jain V, Haragannavar VC, Samuel P, Nayak SR.. Senescence in oral lichen planus as assessed by the immunohistochemical evaluation of senescence marker protein-30 (Regucalcin). Indian Journal of Pathology & Microbiology. 2023 Mar; 66(1): 9-13en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223396
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume66en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_864_21en_US
dc.subjectCellular senescenceen_US
dc.subjectoral lichen planusen_US
dc.subjectoral lichenoid reactionen_US
dc.subjectregucalcinen_US
dc.subjectsenescence marker protein- 30en_US
dc.titleSenescence in oral lichen planus as assessed by the immunohistochemical evaluation of senescence marker protein-30 (Regucalcin)en_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJPM2023v66n1p9.pdf
Size:
1.56 MB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Pathology & Microbiology