Betamethasone in plus phenobarbitone prior to hepatobiliary scintigraphy increases diagnostic accuracy in infants with jaundice.

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dc.contributor.authorGupta, D Ken_US
dc.contributor.authorCharles, A Ren_US
dc.contributor.authorSrinivas, Men_US
dc.contributor.authorDave, Sen_US
dc.contributor.authorBal, C Sen_US
dc.date.accessioned2001-11-05en_US
dc.date.accessioned2009-05-30T12:40:10Z
dc.date.available2001-11-05en_US
dc.date.available2009-05-30T12:40:10Z
dc.date.issued2001-11-05en_US
dc.description.abstractOBJECTIVE: In the diagnostic work up of the child with neonatal obstructive cholangiopathy (NOC), hepatobiliary scintigraphy (HBS) determines the need for peroperative cholangiography (POC). Traditionally, phenobarbitone is recommended to prime the liver to HBS. This retrospective study was designed to evaluate whether addition of the betamethasone (BM) alters the diagnostic accuracy of the HBS in distinguishing neonatal hepatitis (NH) from extra hepatic biliary atresia (EHBA). METHODS: Between 1993-1999, 202 patients presented with NOC and this study was not designed as a prospective randomized clinical trial. Of these, 126 patients had received Phenobarbitone (Group I) and the remaining 76 (Group II) had received BM in addition to the PB in a dose of 5 mg/k/d and 2.2 mg/k/d respectively for 7 days prior to HBS. RESULTS: Retrospective analysis revealed that, in the Group I, 41 showed excretion and 85 did not show any excretion of the radiopharmaceutical and the latter underwent POC which revealed that 31 patients (36%) of them showed patent biliary tract. In group II, 32 patients revealed excretion and 44 did not show any excretion of the radiopharmaceutical and the latter had undergone POC, which revealed that only 8 patients (18%) showed patent biliary tract. The percentages of false positives (36% vs 18%) was statistically significant (p < 0.03). CONCLUSION: Addition of BM increases the diagnostic accuracy of the HBS and this would lead to decreased need for POC to distinguish NH from EHBA.en_US
dc.description.affiliationDepartment of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India. devendra6@hotmail.comen_US
dc.identifier.citationGupta DK, Charles AR, Srinivas M, Dave S, Bal CS. Betamethasone in plus phenobarbitone prior to hepatobiliary scintigraphy increases diagnostic accuracy in infants with jaundice. Indian Journal of Pediatrics. 2001 Nov; 68(11): 1039-41en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/80919
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshBetamethasone --diagnostic useen_US
dc.subject.meshCholestasis, Extrahepatic --diagnosisen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshJaundice, Neonatal --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenobarbital --diagnostic useen_US
dc.subject.meshRadiographic Image Enhancement --methodsen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSensitivity and Specificityen_US
dc.titleBetamethasone in plus phenobarbitone prior to hepatobiliary scintigraphy increases diagnostic accuracy in infants with jaundice.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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