Cryopreservation of cardiac homografts.

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dc.contributor.authorVerghese, Sen_US
dc.contributor.authorSudha, Pen_US
dc.contributor.authorPadmaja, Pen_US
dc.contributor.authorMathew, Ten_US
dc.contributor.authorPrabhakar, Pen_US
dc.contributor.authorArumugam, S Ben_US
dc.contributor.authorMurthy, K Sen_US
dc.contributor.authorCherian, K Men_US
dc.date.accessioned1999-05-07en_US
dc.date.accessioned2009-05-27T04:20:47Z
dc.date.available1999-05-07en_US
dc.date.available2009-05-27T04:20:47Z
dc.date.issued1999-05-07en_US
dc.description.abstractA homograft valve bank for cryopreservation of cardiac homografts was established at the Institute of Cardiovascular Diseases in July 1995. From July 1995 to February 1999, 169 donor hearts were processed. All except four hearts were procured post mortem. Aortic valves (149) and pulmonary valves (139) were the common homografts dissected out for use. The valves were immersed in a cocktail of five broad spectrum antibiotics and antifungals for an average of 48 to 72 hours before cryopreservation. Fifty-three (35.57%) aortic and 42 (30.21%) pulmonary valves had to be discarded for various reasons like fungal contamination, failure to sterilise, HBsAg positivity etc.; 153 homografts have been released for use so far. Analysing the usual methods of procurement, sterilisation protocol, culture and cryopreservation used for cardiac homografts at this centre, this paper recommends observance of timeliness, use of appropriate media for preservation of heart parts, administration of specific drugs and safeguards necessary for cryopreservation procedure.en_US
dc.description.affiliationDepartment of Microbiology, Institute of Cardiovascular Diseases, Madras Medical Mission, Chennai.en_US
dc.identifier.citationVerghese S, Sudha P, Padmaja P, Mathew T, Prabhakar P, Arumugam SB, Murthy KS, Cherian KM. Cryopreservation of cardiac homografts. Indian Heart Journal. 1999 May-Jun; 51(3): 301-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/3847
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshCryopreservationen_US
dc.subject.meshHeart Transplantationen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOrgan Preservationen_US
dc.subject.meshTransplantation, Homologousen_US
dc.titleCryopreservation of cardiac homografts.en_US
dc.typeJournal Articleen_US
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