Anaplastic large cell lymphoma (ALCL) presenting as primary bone and soft tissue sarcoma--a study of 12 cases.

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dc.contributor.authorPant, Vinitaen_US
dc.contributor.authorJambhekar, N Aen_US
dc.contributor.authorMadur, Bhulaxmien_US
dc.contributor.authorShet, T Men_US
dc.contributor.authorAgarwal, Men_US
dc.contributor.authorPuri, Aen_US
dc.contributor.authorGujral, Sen_US
dc.contributor.authorBanavali, Men_US
dc.contributor.authorArora, Ben_US
dc.date.accessioned2007-04-22en_US
dc.date.accessioned2009-05-29T11:26:07Z
dc.date.available2007-04-22en_US
dc.date.available2009-05-29T11:26:07Z
dc.date.issued2007-04-22en_US
dc.description.abstractThis study highlights the rare presentation of anaplastic large cell lymphoma as primary bone and soft tissue tumour. Twelve cases were studied. Clinical impression was non Hodgkin's lymphoma in 4 cases, sarcoma in 6 (osteosarcoma-2, Ewing's/primitive neuroectodermal tumour-1, and sarcoma NOS-3), and tuberculosis of thoracic spine in 1 and the last case involving the rib had a differential diagnosis of tuberculosis and NHL. Histology revealed round cells with eosinophilic cytoplasm and pleomorphic nuclei. Immunohistochemically all tumours were CD30 positive and 8 of 9 cases (88.9%) showed ALK-1 positivity. The pleomorphic cytomorphology ofALCL leads to confusion with the more frequent bone and soft tissue sarcomas affecting the musculoskeletal system. A high index of suspicion is necessary to initiate the correct panel of immunohistochemical markers to first confirm the lymphomatous nature of this tumour and to subsequently subclassify. This alone will lead to an accurate recognition of ALCL and the appropriate chemotherapy.en_US
dc.description.affiliationDepartment of Pathology, Tata Memorial Hospital, Parel, Mumbai.en_US
dc.identifier.citationPant V, Jambhekar NA, Madur B, Shet TM, Agarwal M, Puri A, Gujral S, Banavali M, Arora B. Anaplastic large cell lymphoma (ALCL) presenting as primary bone and soft tissue sarcoma--a study of 12 cases. Indian Journal of Pathology & Microbiology. 2007 Apr; 50(2): 303-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/73511
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshActivin Receptors, Type II --metabolismen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntigens, CD30 --metabolismen_US
dc.subject.meshBone Neoplasms --diagnosisen_US
dc.subject.meshChilden_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLymphoma, Large-Cell, Anaplastic --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshSarcoma --diagnosisen_US
dc.subject.meshSoft Tissue Neoplasms --diagnosisen_US
dc.titleAnaplastic large cell lymphoma (ALCL) presenting as primary bone and soft tissue sarcoma--a study of 12 cases.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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