A three way complex translocation (4; 9; 22) in two patients with chronic myelocytic leukemia.

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dc.contributor.authorSheth, Frenny Jen_US
dc.contributor.authorSheth, Jayesh Jen_US
dc.contributor.authorVerhest, Alainen_US
dc.date.accessioned2005-04-14en_US
dc.date.accessioned2009-06-01T16:24:42Z
dc.date.available2005-04-14en_US
dc.date.available2009-06-01T16:24:42Z
dc.date.issued2005-04-14en_US
dc.description.abstractChronic myeloid leukemia (CML) is genetically characterized by the reciprocal translocation of chromosome 9 and 22, t(9;22)(q34;q11) which results in the fusion of BCR/ABL gene observed on the derivative chromosome 22 called Philadelphia (Ph') chromosome. About 5-8% of Philadelphia positive patients with CML show various complex translocations involving third chromosome in addition to chromosome 9 and 22. In present report we discuss two cases with CML referred at our centre. At the time of initial diagnosis and after 9 months of treatment, one of the patients showed 100% presence of Philadelphia positive in bone marrow culture. During follow-up in an accelerated state, his cytogenetic study revealed a complex translocation (4;9;22)(q25;q34;q11) along with an additional Philadelphia and marker chromosome. The second patient showed a complex (4;9;22)(q25;q34;q11) translocation at the time of diagnosis. He was on hydroxyurea and his follow-up cytogenetic study after the course of chemotherapy showed no changes. Further confirmation of complex translocation was done by FISH study using bcr/abl and whole chromosome 9 probes. Though the additional genes involved in complex variant Ph' rearrangements have not been characterized, both patients are healthy till 3 to 5 years of initial diagnosis. This could be attributed to the benign effect resulted from reciprocal translocation with no loss or gain of the genetic material.en_US
dc.description.affiliationFRIGE (Foundation for Research in Genetics and Endocrinology) Genetic Centre, 20/1, Bima Nagar, Satellite, Ahmedabad-380 015, India. jshethad1@sancharnet.inen_US
dc.identifier.citationSheth FJ, Sheth JJ, Verhest A. A three way complex translocation (4; 9; 22) in two patients with chronic myelocytic leukemia. Journal of Cancer Research and Therapeutics. 2005 Apr-Jun; 1(2): 108-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111532
dc.language.isoengen_US
dc.source.urihttps://www.cancerjournal.neten_US
dc.subject.meshAdulten_US
dc.subject.meshChromosomes, Human, Pair 22en_US
dc.subject.meshChromosomes, Human, Pair 4en_US
dc.subject.meshChromosomes, Human, Pair 9en_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive --geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleA three way complex translocation (4; 9; 22) in two patients with chronic myelocytic leukemia.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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