Clinical profile and management of granulomatosis with polyangiitis–associated scleritis from a tertiary care hospital in South India

Simple item page
dc.contributor.authorMohanan-Earatt, Amandaen_US
dc.contributor.authorBiswas, Jyotirmayen_US
dc.date.accessioned2023-08-25T06:35:46Z
dc.date.available2023-08-25T06:35:46Z
dc.date.issued2023-01
dc.description.abstractPurpose: To describe the clinical features and management of patients with scleritis associated with granulomatosis with polyangiitis (GPA) at a tertiary eye care center in South India. Methods: The clinical profile and management of patients presenting to a tertiary eye care center in South India with scleritis secondary to GPA from 2003 to 2021 were analyzed retrospectively. Scleritis was classified into anterior diffuse, nodular, and necrotizing scleritis with inflammation according to Watson and Hayreh’s classification. Demographic characteristics, clinical features, anti?neutrophil cytoplasmic antibody (ANCA) positivity, treatment response, ocular complications, and status at the last follow?up were analyzed. Statistical analysis of data was performed using Microsoft Excel 2019. Results: Nineteen eyes of 17 patients (15 cytoplasmic staining ANCA [c?ANCA], two p?ANCA positive) were included. Fifteen eyes had necrotizing scleritis, two had diffuse anterior scleritis, and two had nodular scleritis. Remission was induced using a combination of steroids and cyclophosphamide or rituximab. Maintenance therapy was instituted using tapering steroids and immunosuppressants like cyclophosphamide, mycophenolate mofetil, methotrexate, or rituximab. Three eyes required a scleral patch graft. Fourteen patients had good anatomical and visual outcomes, and three were lost to follow?up. Conclusion: GPA is a rare disease, while it is the most common ANCA?associated vasculitis with scleritis. As scleritis may be the presenting sign of the disease, ophthalmologists must be aware of the various features suggestive of GPA. GPA?associated scleritis can have a good prognosis when diagnosed promptly and managed aggressively in the acute stage, and remission is maintained with adequate systemic immunosuppression.en_US
dc.identifier.affiliationsDepartment of Uveitis and Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationMohanan-Earatt Amanda, Biswas Jyotirmay. Clinical profile and management of granulomatosis with polyangiitis–associated scleritis from a tertiary care hospital in South India. Indian Journal of Ophthalmology. 2023 Jan; 71(1): 146-152en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224782
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber1en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1411_22en_US
dc.subjectANCAen_US
dc.subjectgranulomatosis with polyangiitisen_US
dc.subjectscleritisen_US
dc.subjectWegener’s granulomatosisen_US
dc.titleClinical profile and management of granulomatosis with polyangiitis–associated scleritis from a tertiary care hospital in South Indiaen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJO2023v71n1p146.pdf
Size:
2.11 MB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Ophthalmology