Anti-hypertensive Effect of Abelmoschus Esculentus (Okra) Seed Extracts in Fructose-induced Hypertensive Rats
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Date
2019-04
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Scientific Scholar
Abstract
The aim of this study was to investigate the protective activity of ethanolic Abelmoschus esculentus seedextract (EAESE) in fructose-induced Hypertensive rat model. Even though several synthetic drugs have beendiscovered to treat hypertension, it is important to observe the contribution of the daily diet in easing thehypertension and hence the possible therapeutic activity of the seeds from the fruit was studied. The ratswere divided randomly into 4 groups (n=6). Group I was considered as the Normal control. Group II animalswere treated with only 10% w/v Fructose solution for 6 weeks (42 days). Group III animals were treated with10% w/v Fructose solution for 6 weeks (42 days) and EAESE (150 mg/kg bw p.o) after 3 weeks i.e. fromthe 22nd day till the end of the study period (42nd day). Group IV animals were treated with 10% w/v Fructosesolution for 6 weeks (42 days) and Enalapril (10 mg/kg bw p.o) after 3 weeks i.e. from the 22nd day till theend of the study period (42nd day). Physiological parameters ECG, heart rate and blood pressure weremeasured and recorded by the invasive method and the Serum parameters: Total Cholesterol and Triglyceridewere measured.Result: The ECG pattern and Heart rate was improved in the EAESE treated Hypertensive rats. Remarkablereduction in the Blood pressure [systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and meanarterial pressure (MAP)] levels were observed along with a significant reduction in the Total cholesterol andTriglyceride levels.Conclusion: From the results obtained, it can be suggested that the ethanolic extract of Abelmoschusesculentus seeds has the potential antihypertensive activity as well anti-hyperlipidaemic activity.
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Mondal Kallolika, K.P. Shivalinge Gowda, Manandhar Suman. Anti-hypertensive Effect of Abelmoschus Esculentus (Okra) Seed Extracts in Fructose-induced Hypertensive Rats. Indian Journal of Physiology and Pharmacology. 2019 Apr; 2: 175-181