Different roles of histamine receptor subtypes in ampullar & isthmic segments of human fallopian tube.

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dc.contributor.authorJanković, S Men_US
dc.contributor.authorVarjacić, Men_US
dc.contributor.authorJanković, S Ven_US
dc.date.accessioned1998-05-22en_US
dc.date.accessioned2009-05-27T07:06:48Z
dc.date.available1998-05-22en_US
dc.date.available2009-05-27T07:06:48Z
dc.date.issued1998-05-22en_US
dc.description.abstractWe have studied the influence of both menstrual cycle phase and subtype-selective histamine antagonists on the contractions produced by histamine isolated in human fallopian tubes. Histamine produced tonic contractions of the isolated preparations of both the ampullar and isthmic segments of the human fallopian tube were analyzed. The effects of both histamine and its antagonists were not dependent on the phase of the menstrual cycle. The isolated preparations of the ampullar segment from post menopausal patients were not responsive on histamine. When responding, the ampullar segments were slightly more sensitive to histamine than the isthmic segments. All three subtype selective histamine antagonists (pyrilamine, cimetidine and thioperamide) produced strong inhibition of histamine evoked contractions of the ampullar segment. On the other hand, only pyrilamine strongly inhibited histamine evoked contractions of the isthmic segment. The results of our study suggest that only H1 receptors were responsible for the histamine contractile effect on the isthmic segment and that all three subtypes of histamine receptors were involved in the effect of histamine on the ampullar segment of human fallopian tube.en_US
dc.description.affiliationDepartment of Pharmacology, Medical Faculty, Kragujevac, Serbia.en_US
dc.identifier.citationJanković SM, Varjacić M, Janković SV. Different roles of histamine receptor subtypes in ampullar & isthmic segments of human fallopian tube. Indian Journal of Medical Research. 1998 May; 107(): 224-30en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19352
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshFallopian Tubes --anatomy & histologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHistamine --pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMuscle Contraction --drug effectsen_US
dc.subject.meshMuscle, Smooth --physiologyen_US
dc.subject.meshReceptors, Histamine --physiologyen_US
dc.titleDifferent roles of histamine receptor subtypes in ampullar & isthmic segments of human fallopian tube.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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