Evaluation of cysticercus fasciolaris antigen for the immunodiagnosis of neurocysticercosis.

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dc.contributor.authorHusain, Nen_US
dc.contributor.authorJyotsna,en_US
dc.contributor.authorBagchi, Men_US
dc.contributor.authorHusain, Men_US
dc.contributor.authorMishra, M Ken_US
dc.contributor.authorGupta, Sen_US
dc.date.accessioned2001-12-19en_US
dc.date.accessioned2009-06-03T10:58:21Z
dc.date.available2001-12-19en_US
dc.date.available2009-06-03T10:58:21Z
dc.date.issued2001-12-19en_US
dc.description.abstractCysticercus cellulosae antigen has been frequently used to detect antibodies for immunodiagnosis of neurocysticercosis. We have, for the first time, used membrane extract of cysticercus fasciolaris, the larval stage of Taenia taeniaeformis, in ELISA, with successful results. IgM and IgG antibodies against cysticercus were measured in serum from cases of neurocysticercosis (217), normal and diseased controls (89). 203 sera from cases of neurocysticercosis were positive for either or both IgG and IgM antibodies while 157/217 cases showed IgM and 158/217 showed IgG antibodies. Ten controls showed false postivity in IgG ELISA. Eight of these cases also had IgM antibodies. The test had an overall sensitivity of 93.54% and a specificity of 84.2% with a positive predictive value of 93.54% and a negative predictive value of 84.2%. Cysticercus fasciolaris can be conveniently produced in the experimental laboratory host, Rattus rattus, and would be of practical value in the immunodiagnosis of cysticercosis in humans.en_US
dc.description.affiliationDepartment of Pathology, King George's Medical College, Lucknow - 226003, India. drnuzhathusain@hotmail.comen_US
dc.identifier.citationHusain N, Jyotsna , Bagchi M, Husain M, Mishra MK, Gupta S. Evaluation of cysticercus fasciolaris antigen for the immunodiagnosis of neurocysticercosis. Neurology India. 2001 Dec; 49(4): 375-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/120578
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Helminth --analysisen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCysticercus --immunologyen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assay --methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunologic Tests --methodsen_US
dc.subject.meshNeurocysticercosis --diagnosisen_US
dc.subject.meshRatsen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleEvaluation of cysticercus fasciolaris antigen for the immunodiagnosis of neurocysticercosis.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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