Leukemia in infants.

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dc.contributor.authorSomjee, Saikaen_US
dc.contributor.authorSapre, Rupaen_US
dc.contributor.authorShinde, Shailaen_US
dc.contributor.authorKumar, Ashoken_US
dc.contributor.authorDhond, Subodhen_US
dc.contributor.authorBadrinath, Yen_US
dc.contributor.authorMahadik, Shashikanten_US
dc.contributor.authorChougale, Anuradhaen_US
dc.contributor.authorAnsari, Rasheedaen_US
dc.contributor.authorNair, C Nen_US
dc.contributor.authorAdvani, S Hen_US
dc.date.accessioned2002-03-11en_US
dc.date.accessioned2009-05-30T12:02:04Z
dc.date.available2002-03-11en_US
dc.date.available2009-05-30T12:02:04Z
dc.date.issued2002-03-11en_US
dc.description.abstractOBJECTIVE: Acute Leukemia is rare in infants. It is characterized by non-specific symptomatology requiring a high index of suspicion on the part of a pediatrician for referral and diagnosis. It has peculiar biological features, unresponsiveness to treatment and poor prognosis. METHODS: Eighteen infants with acute leukemia were seen during 1994 to 2001 and were analyzed on the basis of clinical and laboratory data. There were 13 cases of Acute Lymphoblastic Leukemia (ALL), 4 cases of Acute Myeloid Leukemia (AML) and one case remained unclassifiable, as the surface markers could not be done. Morphologically 9/13 cases of ALL were of FAB L1 type and remaining of L2 subtype, and 2/4 cases of AML were of FAB M1 type and remaining of M2 subtype. RESULT: Clinical data was available completely only in 11 cases. Hyperleucocytosis was present in 4 cases, organomegaly in 8 cases and lympadenopathy in 5 cases. One patient presented with a chloroma in the retrorbital region although there was no parenchymal involvement of the brain. Immunophenotyping could be done in 13 cases, where 7 cases were diagnosed as CALLA positive-ALL (HLADR+, CD19+, CD10+), 2 cases as Early Pre-B ALL (HLADR+, CD19+, CD10 negative), one as T ALL (cCD3+, CD2+, CD7+) and 3 cases as AML (CD13+, CD33+, HLADR+). None of our patients received treatment.en_US
dc.description.affiliationDepartment of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India. saikal@rediffmail.comen_US
dc.identifier.citationSomjee S, Sapre R, Shinde S, Kumar A, Dhond S, Badrinath Y, Mahadik S, Chougale A, Ansari R, Nair CN, Advani SH. Leukemia in infants. Indian Journal of Pediatrics. 2002 Mar; 69(3): 225-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/80277
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshLeukemia --immunologyen_US
dc.subject.meshMaleen_US
dc.titleLeukemia in infants.en_US
dc.typeJournal Articleen_US
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