Signatures of positive selection on the hepatic lipase gene in human populations

Simple item page
dc.contributor.authorFlores, Sergio V.en_US
dc.contributor.authorOLIVARI, Carla F.en_US
dc.contributor.authorPRADO, Luis Floresen_US
dc.date.accessioned2020-11-18T10:21:11Z
dc.date.available2020-11-18T10:21:11Z
dc.date.issued2020-01
dc.description.abstractThe hepatic lipase plays a central role in the lipid metabolism, catalyzing the hydrolysis of phospholipids, monoglycerides, diglycerides, and triglycerides, and acyl-CoA. It is also implied in the conversion of very low-density lipoprotein and intermediate density lipoprotein to low density lipoproteins. As a consequence, the gene encoding the hepatic lipase (LIPC) is associated with several diseases derived from the imbalance of lipids that are in general derived from the interaction between life styles and genetic architecture. Therefore, it is interesting to understand more about the characteristics of the microevolutionary processes affecting genes that, like LIPC, have a role in nutrition and lipid metabolism in human populations. We explored the selection signatures on LIPC in 26 populations, detecting three regions under recent positive selectionen_US
dc.identifier.affiliationsLaboratorio de Gene´tica y Bioantropologı´a, Departamento de Antropologı´a, Facultad de Ciencias Sociales, Universidad de Chile, Avenida Ignacio Carrera Pinto 1045, N˜ un˜oa 7750000, Santiago, Chileen_US
dc.identifier.affiliationsPresent Address: Labortorio de Geno´mica Evolutiva, N˜ un˜oa 7750000, Santiago, Chileen_US
dc.identifier.affiliationsLaboratorio de Gene´tica y Bioantropologı´a, Departamento de Antropologı´a, Facultad de Ciencias Sociales, Universidad de Chile, Avenida Ignacio Carrera Pinto 1045, N˜ un˜oa 7750000, Santiago, Chileen_US
dc.identifier.affiliationsInstituto de Entomologı´a, Universidad Metropolitana de Ciencias de la Educacio´n, N˜ un˜oa 7750000, Santiago, Chileen_US
dc.identifier.citationFlores Sergio V., Olivari Carla F., Prado Luis Flores. Signatures of positive selection on the hepatic lipase gene in human populations. Journal of Genetics. 2020 Jan; 99: 1-5en_US
dc.identifier.issn0022-1333
dc.identifier.issn0973-7731
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215564
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.volume99en_US
dc.source.urihttps://doi.org/10.1007/s12041-019-1160-8en_US
dc.subjecthepatic lipaseen_US
dc.subjectpositive selectionen_US
dc.subjectTajima’s Den_US
dc.subjectFu and Li testen_US
dc.subject1000 genomes.en_US
dc.titleSignatures of positive selection on the hepatic lipase gene in human populationsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jmsh2019v99pffff1.pdf
Size:
384.94 KB
Format:
Adobe Portable Document Format
Download
Collections
Journal of Genetics