Effect of Ca++ channel blockers and saralasin on angiotensin II induced contraction in rabbit aortic strip.

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dc.contributor.authorKheterpal, Ken_US
dc.contributor.authorLall, S Ben_US
dc.contributor.authorRajdev, Sen_US
dc.contributor.authorGupta, Y Ken_US
dc.date.accessioned1986-04-01en_US
dc.date.accessioned2009-06-01T08:31:53Z
dc.date.available1986-04-01en_US
dc.date.available2009-06-01T08:31:53Z
dc.date.issued1986-04-01en_US
dc.description.abstractTo investigate the role of calcium in angiotensin II (A II) induced contractions in rabbit aortic strip, the action of verapamil, nifedipine, cinnarizine and saralasin was studied. The cumulative dose response curves obtained with A II shifted to right with increasing concentrations of all these four agents. The antagonism was noncompetitive. The pD'2 value of saralasin was 8.49 of nifedipine, 8.15 and or verapamil 7.92. Cinnarizine which mainly acts at intracellular site had pD'2 value 5.54. The results indicate that A II induced contractions critically depend on entry of calcium through channels which appear to be closely associated with angiotensin receptors.en_US
dc.identifier.citationKheterpal K, Lall SB, Rajdev S, Gupta YK. Effect of Ca++ channel blockers and saralasin on angiotensin II induced contraction in rabbit aortic strip. Indian Journal of Physiology and Pharmacology. 1986 Apr-Jun; 30(2): 166-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108977
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAngiotensin II --antagonists & inhibitorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium Channel Blockers --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSaralasin --pharmacologyen_US
dc.subject.meshVasoconstriction --drug effectsen_US
dc.titleEffect of Ca++ channel blockers and saralasin on angiotensin II induced contraction in rabbit aortic strip.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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