Loop Diuretics: An Overview of Its History and Evolution
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Date
2024-09
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Journal of Indian Medical Association
Abstract
The loop of Henle plays a key role in kidney function, especially in retaining solutes and concentrating urine. Diuretic agents, crucial for managing fluid overload and related conditions like hypertension and heart failure (HF), enhance water and electrolyte excretion. The history of diuretics dates back to 1775 with the discovery of Digitalis, evolving significantly with the introduction of chlorothiazide in 1957, which revolutionized diuretic therapy. Loop diuretics, developed in the 1950s and including drugs like torsemide, furosemide, and ethacrynic acid, are potent agents acting on the loop of Henle. They are vital for treating severe fluid overload conditions and require careful monitoring to manage potential side effects.
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Pal Jyotirmoy, Tiwaskar Mangesh, Garg Salil, Khare Avadhesh Narayan, Patil Sachin, Bhutani Jaikrit, Gupta Abhinav, Srinivas Sandeep, Nambirajan Ganesan, Reddy Ranga, Singh Ajay Pratap, Kashyap Umesh, Zalte Nitin, Sugumaran Amarnath. Loop Diuretics: An Overview of Its History and Evolution. Journal of the Association of Physicians of India. 2024 Sep; 72(9): 11–13