Comparative Study of Antibiotics and Allium Sativum Against Coagulase Positive and Coagulase Negative Staphylococcus.
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Date
2014-12
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Abstract
Garlic (Allium sativum) is a well known
medicine used since ancient times. Its potency as an
antibiotic without inducing drug resistance has been well
documented. A very common pyogenic organism, namely
Staphylococcus aureus, as well as its coagulase negative
brethren, are very well known pathogens causing infections
all over the world. Their ability to become multidrug resistant
has become a matter of deep concern to medical personnels
all over the world. We wanted to see that garlic, described
in various literatures as antiviral, antibacterial, antifungal,
antiprotozoal, antioxidant – held how much potency as an
antistaphylococcal agent as well. Aims and Objectives: The
study aimed at evaluating the antistaphylococcal activity of
garlic, in the face of emergence of multidrug resistant forms
of both coagulase positive and negative forms of
staphylococcus. Materials and Methods: Raw garlic juice
was extracted and was tested to be sterile. Pure cultures of
coagulase positive and negative staphylococcus were
prepared. A comparative study using six potent antibiotics
as well as garlic against Staphylococcus and CoNS strains
was done. At the same time, decreasing concentrations of
garlic solution was used to show the effect on zone of
inhibition. Discussion: Both S.aureus and CoNS strains
showed significant inhibition by garlic extract. Garlic seemed
to have greater antibacterial effect than all the antibiotics
tested except linezolid, which persistently performed better.
With decreasing concentration of garlic juice, zone of
inhibition also decreased consistently.
Description
Keywords
staphylococcus, allium sativum, antibacterial effect
Citation
Chattopadhyay Monojit, Banerjee Dibyendu, Chakraborty Baishali, Datta Saikat Prasad, Bera Swati. Comparative Study of Antibiotics and Allium Sativum Against Coagulase Positive and Coagulase Negative Staphylococcus. Indian Medical Gazette. 2014 Dec ; 148 (12): 457-462.