Phytochemical compounds of anise hyssop (Agastache foeniculum) and antibacterial, antioxidant, and acetylcholinesterase inhibitory properties of its essential oil

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dc.contributor.authorIvanov, Ivan G.en_US
dc.contributor.authorVrancheva, Radka Z.en_US
dc.contributor.authorPetkova, Nadezhda T.en_US
dc.contributor.authorTumbarski, Yulianen_US
dc.contributor.authorIvayla, N. Dinchevaen_US
dc.contributor.authorBadjakov, Ilian K.en_US
dc.date.accessioned2020-10-16T08:55:53Z
dc.date.available2020-10-16T08:55:53Z
dc.date.issued2019-02
dc.description.abstractAgastache foeniculum (Pursh) Kuntze (anise hyssop) is known as a medicinal and flavoring spice plant. The aim ofthis research was gas chromatography-mass spectrometry (GC-MS) analysis of anise hyssop essential oil and analysisof radical scavenging ability, antimicrobial activity, and acetylcholinesterase inhibitory activity. Phytochemicalcomposition of anise hyssop wastes and the aqueous extract obtained after steam distillation was investigated.Eight compounds were identified in essential oils by GC-MS analysis, as the major ones were phenylpropenoids[estragol—93.45% of total ion current (TIC), eugenol—0.15% of TIC, and methyl isoeugenol—2.48% of TIC]. Inthe anise hyssop wastes extract, four pentacyclic triterpenes were identified (betulin—36.1 mg/g, betulinic acid—2.4mg/g, oleanolic acid—160.0 mg/g, and ursolic acid—6.7 mg/g extract). Rosmarinic acid (50.6 mg/g extract) andflavonoids—myricetin (0.5 mg/g), luteolin (0.9 mg/g), and apigenin (0.6 mg/g) were detected by high-performanceliquid chromatography with diode-array detection analysis of aqueous extract. The anise hyssop essential oil showedstrong radical scavenging ability IC50—6.54 μl/ml. The results obtained from antimicrobial screening revealed thatessential oil possessed inhibitory activity against Staphylococcus aureus ATCC 25923, Curtobacterium flaccumfaciensPM_YT, Listeria monocytogenes, Bacillus subtilis ATCC 6633, Salmonella sp., Escherichia coli ATCC 8739, Proteusvulgaris, Pseudomonas aeruginosa ATCC 9027, Klebsiella pneumoniae, and Candida albicans, while Enterococcusfaecalis remained unaffected.en_US
dc.identifier.affiliationsDepartment of Organic Chemistry and Inorganic Chemistry, University of Food Technologies, Plovdiv, Bulgariaen_US
dc.identifier.affiliationsDepartment of Analytical Chemistry and Physical Chemistry, University of Food Technologies, Plovdiv, Bulgariaen_US
dc.identifier.affiliationsDepartment of Organic Chemistry and Inorganic Chemistry, University of Food Technologies, Plovdiv, Bulgaria.en_US
dc.identifier.affiliationsDepartment of Microbiology, University of Food Technologies, Plovdiv, Bulgariaen_US
dc.identifier.affiliationsAgroBioInstitute, Agricultural Academy, Sofia, Bulgariaen_US
dc.identifier.affiliationsAgroBioInstitute, Agricultural Academy, Sofia, Bulgariaen_US
dc.identifier.citationIvanov Ivan G., Vrancheva Radka Z., Petkova Nadezhda T., Tumbarski Yulian, Ivayla N. Dincheva, Badjakov Ilian K.. Phytochemical compounds of anise hyssop (Agastache foeniculum) and antibacterial, antioxidant, and acetylcholinesterase inhibitory properties of its essential oil. Journal of Applied Pharmaceutical Science. 2019 Feb; 2019 Feb: 072-078en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210525
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber2en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.90210en_US
dc.subjectAgastache foeniculumen_US
dc.subjectessential oilen_US
dc.subjectpentacyclic triterpenesen_US
dc.subjectantimicrobial activityen_US
dc.subjectantioxidant activityen_US
dc.subjectrosmarinic acid.en_US
dc.titlePhytochemical compounds of anise hyssop (Agastache foeniculum) and antibacterial, antioxidant, and acetylcholinesterase inhibitory properties of its essential oilen_US
dc.typeJournal Articleen_US
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