The spectrum of pathologic lesions in spleen in patients with acquired immunodeficiency syndrome: Autopsy report of 257 patients

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dc.contributor.authorLanjewar, Dhaneshwar N.en_US
dc.contributor.authorKavatkar, Anita N.en_US
dc.date.accessioned2025-05-09T09:57:06Z
dc.date.available2025-05-09T09:57:06Z
dc.date.issued2024-09
dc.description.abstractBackground: Human immunodeficiency virus (HIV) infection continues to persist in India over the past three decades. The involvement of the spleen in these patients has a wide array of differentials with opportunistic infections and malignancies. The spectrum of splenic lesions in patients with HIV/AIDS has not been described in the Indian literature. Materials and Methods: A retrospective study was designed to understand the spectrum of splenic pathology in patients with HIV/AIDS. The specimens of the spleen obtained at autopsy in 257 patients over a period of 29 years were systematically analyzed. Results: Among 257 patients, 197 (77%) were males and 60 (23%) were females with a heterosexual route of transmission in 246 (96%) patients. There were 236 (92%) patients from the pre?highly active anti?retroviral therapy era, while 21 (8%) patients had received highly active anti?retroviral therapy for a short duration. The most frequent splenic pathology identified was tuberculosis, noted in 135 (52%) patients, manifesting as military lesions (119 patients, 46%), tuberculous abscesses (13 patients, 5%), and tuberculosis associated with splenic infarcts (03, 1%) patients. The other pathologies noted were cryptococcosis in 17 (7%) patients, malarial infection in 13 (5%) patients, and cytomegalovirus infection in 01 (0.5%) patient. The other findings identified were chronic passive venous congestion, perivascular fibrosis, hemosiderosis, and amyloidosis. In addition, absence or depletion of lymphocyte was noted in 98 (38%) patients and in 4 (1.5%) patients diffuse large B?cell lymphoma was found. Conclusions: Patients with HIV/AIDS presenting with splenic lesions have a wide array of differentials, such as tuberculosis, opportunistic infection, and the lymphoma. This study provides a better insight into the splenic lesions in patients with AIDS in India.en_US
dc.identifier.affiliationsDepartment of Pathology, Gujarat Adani Institute of Medical Sciences, Bhuj, Kachchh, Gujarat, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, B. J. Government Medical College, Pune, Maharashtra, Indiaen_US
dc.identifier.citationLanjewar Dhaneshwar N., Kavatkar Anita N. . The spectrum of pathologic lesions in spleen in patients with acquired immunodeficiency syndrome: Autopsy report of 257 patients. Indian Journal of Pathology & Microbiology. 2024 Sep; 67(3): 553-558en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245480
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber3en_US
dc.relation.volume67en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_985_22en_US
dc.subjectAIDSen_US
dc.subjectAutopsyen_US
dc.subjectcryptococcosisen_US
dc.subjectspleenen_US
dc.subjecttuberculosisen_US
dc.titleThe spectrum of pathologic lesions in spleen in patients with acquired immunodeficiency syndrome: Autopsy report of 257 patientsen_US
dc.typeJournal Articleen_US
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