Malignant Transformation in Mature Cystic Dermoid: A Case Series of 8 Cases

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dc.contributor.authorSontakke(Ingle), Bhavanaen_US
dc.contributor.authorParekh, Chetanaen_US
dc.contributor.authorPatel, Shilpa Men_US
dc.contributor.authorArora, Ruchien_US
dc.date.accessioned2023-07-14T08:10:03Z
dc.date.available2023-07-14T08:10:03Z
dc.date.issued2021-12
dc.description.abstractIntroduction: One of the most common types of ovarian germ neoplasm is Mature cystic teratoma(MCT) which accounts for almost 20% of all ovarian neoplasm. Objective: Analyze patients with Malignant Transformation (Mt) arising from Mature Cystic Teratoma of the ovary to evaluate Clinico-pathological features and treatment modalities. Methods: This is an observational study of 8 patients of Mt in MCT, who had taken complete treatment at GCRI between the period from September 2016 to September 2021. During this observation period, a total of two thousand one hundred and seventy seven ovarian tumors were diagnosed. Out of these patients, 9.32% (203) were MCTs. Of the consecutive cases of 203 ovarian MCTs diagnosed, 3.9% (8) had Mt of MCT, which was our study group. Results: The mean age of patients with Mt in MCT was 47.1 years (27- 65 yrs), while mean age of the patients with MCT was 42 years (35-55 years). Among the 21 postmenopausal, MCT's 28.5% (6) cases developed Mt and only 1% i.e., two cases from premenopausal showed Mt. Abdominal pain as main symptom was seen in 87.5% (7/8) patients. The duration of symptoms ranged from 3 to 6 months. CA125 was elevated in 75% patients. Germ cell markers including beta HCG, AFP, LDH were found to be normal. Conclusion: Diagnosis of malignant transformation of MCT is very difficult. There should be high index of suspicion of malignant transformation if the MCT has been present for a long time; the patient is postmenopausal, age>45 yrs; the tumor diameter is greater than 9.5 cm; or there is thickening of the cyst wall or papillary growth occurs, increased tumor markersen_US
dc.identifier.affiliationsFellowen_US
dc.identifier.affiliationsProfessoren_US
dc.identifier.affiliationsProfessor & Head. Department of Gynaecological Oncology, Gujarat Cancer & Research Institute (GCRI), Civil Hospital Campus, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.citationSontakke(Ingle) Bhavana, Parekh Chetana, Patel Shilpa M, Arora Ruchi. Malignant Transformation in Mature Cystic Dermoid: A Case Series of 8 Cases. GCSMC Journal of Medical Sciences. 2022 Dec; 11(2): 11-17en_US
dc.identifier.issn2278-7399
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219701
dc.languageenen_US
dc.publisherGCS Medical College, Hospital and Research Centeren_US
dc.relation.issuenumber2en_US
dc.relation.volume11en_US
dc.source.urihttps://gcsmc.org/assets/pdf/journal/journal-2218/original-article/2.pdfen_US
dc.subjectCystic dermoiden_US
dc.subjectMalignancyen_US
dc.subjectMature Cystic Teratomaen_US
dc.subjectOvarian neoplasmen_US
dc.titleMalignant Transformation in Mature Cystic Dermoid: A Case Series of 8 Casesen_US
dc.typeJournal Articleen_US
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