Effect of lignocaine on blood lipid in relation to partition coefficient and biological activity.
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1991-06-01
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Abstract
To correlate lipophilicity of lignocaine with changes in lipid composition of blood as a result of in vitro incubation with the drug, phosphorus content and fatty acid compositions of blood lipids before and after lignocaine treatment have been compared with those of a standard phospholipid, lecithin, under similar conditions of drug treatment. The change in fatty acid constituents has been correlated with the biological activity (both therapeutic and toxic) of lignocaine.
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Dutta H, Sengupta M, Ghosh A, Sengupta C, De AU. Effect of lignocaine on blood lipid in relation to partition coefficient and biological activity. Indian Journal of Biochemistry & Biophysics. 1991 Jun; 28(3): 210-3