Serum TNF-alpha and free radical scavengers in neonatal septicemia.

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dc.contributor.authorSeema,en_US
dc.contributor.authorKumar, Ren_US
dc.contributor.authorMandal, R Nen_US
dc.contributor.authorTandon, Aen_US
dc.contributor.authorRandhawa, V Sen_US
dc.contributor.authorMehta, Gen_US
dc.contributor.authorBatra, Sen_US
dc.contributor.authorRay, G Nen_US
dc.contributor.authorKapoor, A Ken_US
dc.date.accessioned1999-07-08en_US
dc.date.accessioned2009-05-30T15:46:26Z
dc.date.available1999-07-08en_US
dc.date.available2009-05-30T15:46:26Z
dc.date.issued1999-07-08en_US
dc.description.abstractTumor necrosis factor-alpha (TNF-alpha) and free radicals have been implicated in the pathogenesis of neonatal septicemia and its complications. This case control study was conducted between November 1996 to July 1997 to determine the levels of TNF-alpha and free radical scavengers viz. superoxide dismutase (SOD) and glutathione peroxidase (GPX) in the serum of 30 septic neonates and 20 healthy controls. Patients with neonatal sepsis registered significantly higher levels of TNF-alpha, SOD and GPX in comparison to controls (p < 0.05). The neonates with septic shock had five fold increase in TNF-alpha levels (2262 +/- 605.8 pg/ml) as compared to those without shock (738.8 +/- 728.8 pg/ml). There was no statistically significant difference in levels of antioxidant enzymes between neonates with shock and without shock. The levels of TNF-alpha and antioxidant enzymes were not affected by the type of organism isolated in blood culture.en_US
dc.description.affiliationDepartment of Pediatrics, Kalawati Saran Children's Hospital, New Delhi.en_US
dc.identifier.citationSeema , Kumar R, Mandal RN, Tandon A, Randhawa VS, Mehta G, Batra S, Ray GN, Kapoor AK. Serum TNF-alpha and free radical scavengers in neonatal septicemia. Indian Journal of Pediatrics. 1999 Jul-Aug; 66(4): 511-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/83937
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFree Radical Scavengers --blooden_US
dc.subject.meshGlutathione Peroxidase --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshSepsis --blooden_US
dc.subject.meshSuperoxide Dismutase --blooden_US
dc.subject.meshTumor Necrosis Factor-alpha --analysisen_US
dc.titleSerum TNF-alpha and free radical scavengers in neonatal septicemia.en_US
dc.typeJournal Articleen_US
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