Determination of minimal inhibitory concentration of citric acid as a root canal irrigant against E. faecalis and C. albicans

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dc.contributor.authorRavi, Aen_US
dc.contributor.authorEphraim, Ren_US
dc.contributor.authorBelchada, DKen_US
dc.contributor.authorKanadan, A.en_US
dc.date.accessioned2025-08-13T08:48:06Z
dc.date.available2025-08-13T08:48:06Z
dc.date.issued2025-03
dc.description.abstractThe clinical success of primary teeth endodontic therapy depends strongly on attaining prepared root canals with sufficient disinfection levels. Therefore, using natural or chemical cleaning agents to properly clean the root canals is becoming more and more important. With little to no impact on the organic components, citric acid is effective in dissolving the smear layer and the inorganic components of root dentine. Study included the custom preparation of citric acid to 3 different concentrations-6,8, and 10%. MTCC strains of C. albicans and E. faecalis were cultured on Sabouraud Dextrose agar plates and blood agar respectively. Three wells each were prepared on cultured plates and the solutions of citric acid was inoculated into them. The zone of inhibition was noted after 24 hours in each plate. The greatest zone of inhibition will be determined in each of the plates and the concentration was recorded with E. Faecalis and C. Albicans. The lowest concentration of citric acid that is capable of inhibiting bacterial growth will be taken as the minimum inhibitory concentration of citric acid against the respective organism. 8% concentration of citric acid can be used as an irrigant and gives a greater inhibition zone almost as much as that of 10 % citric acid.en_US
dc.identifier.affiliationsDepartment of Pediatric and Preventive Dentistry, Mahe Institute of Dental Science and Hospital, Chalakkara, Palloor, Mahe, UT of Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatric and Preventive Dentistry, Mahe Institute of Dental Science and Hospital, Chalakkara, Palloor, Mahe, UT of Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatric and Preventive Dentistry, Mahe Institute of Dental Science and Hospital, Chalakkara, Palloor, Mahe, UT of Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatric and Preventive Dentistry, Mahe Institute of Dental Science and Hospital, Chalakkara, Palloor, Mahe, UT of Puducherry, Indiaen_US
dc.identifier.citationRavi A, Ephraim R, Belchada DK, Kanadan A.. Determination of minimal inhibitory concentration of citric acid as a root canal irrigant against E. faecalis and C. albicans . International Journal of Clinical Trials. 2025 Mar; 12(1): 59-64en_US
dc.identifier.issn2349-3240
dc.identifier.issn2349-3259
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/250225
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2349-3259.ijct20250134en_US
dc.subjectCitric aciden_US
dc.subjectC. albicansen_US
dc.subjectE. faecalisen_US
dc.subjectRoot canal irriganten_US
dc.titleDetermination of minimal inhibitory concentration of citric acid as a root canal irrigant against E. faecalis and C. albicansen_US
dc.typeJournal Articleen_US
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