Role of statins in the management of dyslipidaemia
No Thumbnail Available
Date
2024-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Blood cholesterol has firmly been established as a crucial risk factor for the development of atherosclerotic cardiovascular disease (ASCVD) by elegant epidemiological studies. Naturally, means to reduce blood cholesterol level took the centerstage of research in this field. After initial lukewarm results with nicotinic acid, fibrates and some other agents, statins emerged as the most effective class of medicine to reduce blood cholesterol; in particular, the most atherogenic low density lipoprotein cholesterol (LDL-C). Also, they are very safe and well tolerated. As ASCVD comes in various stages, statins have also been tried in different settings, e.g., primary prevention, secondary prevention, as part of coronary intervention strategy, familial hypercholesterolemia, etc. Almost in all clinical scenarios, statins proved themselves to impart clinical benefit. Though side effects of statins are outweighed by their benefits, nonetheless clinicians should detect the side effects early to avoid major problems.
Description
Keywords
Cholesterol, Statin, Atherosclerotic cardiovascular disease, Familial hypercholesterolemia, Metabolic syndrome
Citation
Ray Saumitra . Role of statins in the management of dyslipidaemia. Indian Heart Journal. 2024 Mar; 76(1): 33-37