Comparison of plasma ascorbate status between diabetic retinopathy subjects with and without photo-coagulation therapy.

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dc.contributor.authorChakraborty, S Ken_US
dc.date.accessioned1993-08-01en_US
dc.date.accessioned2009-05-27T03:47:17Z
dc.date.available1993-08-01en_US
dc.date.available2009-05-27T03:47:17Z
dc.date.issued1993-08-01en_US
dc.descriptionBangladesh Medical Research Council Bulletin.en_US
dc.description.abstractMetabolism of ascorbic acid is deranged in Diabetes Mellitus (DM). One important reason of this derangement is its increased turnover in the process of handling an increased load of free radicals. Anoxia, the triggering factor in the pathogenesis of diabetic retinopathy generates free radicals in anoxia-reperfusion sequence. Any process like argon laser photocoagulation that destroys the anoxic sites and improves oxygenation in retina might hinder the process of generation of free radicals and thus expected to preserve ascorbic acid. In this study plasma total ascorbic acid concentration in matched groups of (I) diabetics with retinopathy with no history of photocoagulation (II) diabetics with retinopathy treated by laser and (III) diabetics without microvascular pathology were measured by 2-4 dinitrophenyl hydrazine method. Plasma total ascorbate concentration was significantly higher in group-II (0.47 +/- 0.09 mg/dl; X +/- SD) in comparison to group-I (0.19 +/- 0.07 mg/dl P < 0.001). The concentration was not significant between group-II and group-III (0.49 +/- 0.06 mg/dl; P = 0.40). Other clinical and metabolic parameters were not significantly different in between the groups. This observation leads to speculation that photocoagulation saves ascorbic acid from excessive turnover in anoxic retina in the process of handling free radicals.en_US
dc.description.affiliationDeptt. of Pathology, Chittagong Medical College.en_US
dc.identifier.citationChakraborty SK. Comparison of plasma ascorbate status between diabetic retinopathy subjects with and without photo-coagulation therapy. Bangladesh Medical Research Council Bulletin. 1993 Aug; 19(2): 39-44en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/411
dc.language.isoengen_US
dc.source.urihttps://www.banglajol.info/index.php/BMRCB/indexen_US
dc.subject.meshAscorbic Acid --blooden_US
dc.subject.meshDiabetic Retinopathy --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLaser Coagulationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleComparison of plasma ascorbate status between diabetic retinopathy subjects with and without photo-coagulation therapy.en_US
dc.typeJournal Articleen_US
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