Evaluation of key histologic variables in skin biopsies of patients of borderline leprosy with type 1 lepra reaction.

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dc.contributor.authorPatnaik, Nivedita
dc.contributor.authorAgarwal, Sarla
dc.contributor.authorSharma, Sonal
dc.contributor.authorSharma, Satendra
dc.contributor.authorPandhi, Deepika
dc.date.accessioned2015-01-09T10:48:42Z
dc.date.available2015-01-09T10:48:42Z
dc.date.issued2014-09
dc.description.abstractBackground: Leprosy remains an important health problem mainly in the African and South-East Asia regions. Type 1 reaction is an immune-mediated phenomenon known to complicate at least 30% of patients of leprosy. Diagnosing type 1 reaction correctly is important for timely institution of therapy to prevent and treat neuropathy-associated disability and morbidity. There is paucity of literature on definitive criteria for histologic diagnosis of type 1 reaction. This study was conducted to determine the key histologic variables for diagnosing type 1 reaction. Methods: This was a prospective study recruiting 104 patients with borderline leprosy. Three pathologists blinded to the clinical diagnosis independently assessed the cases. The agreement between each histological variable and clinical diagnosis was then calculated by using Cohen's kappa (Κ) coefficient. Results: Histological diagnosis of type 1 reaction was given to 27 (67.5%) of 40 clinically diagnosed cases of type 1reaction cases. Histological variables chosen as key variables for histological diagnosis of type 1 reaction were presence of giant cells, dermal edema, intragranuloma edema, granuloma fraction 31-50%, and presence of medium to large giant cells. Conclusion: This study has shown that T1R are still underdiagnosed histologically in comparison with clinical assessments. The key variables for diagnosing type 1 reaction were proposeden_US
dc.identifier.citationPatnaik Nivedita, Agarwal Sarla, Sharma Sonal, Sharma Satendra, Pandhi Deepika. Evaluation of key histologic variables in skin biopsies of patients of borderline leprosy with type 1 lepra reaction. Indian Journal of Dermatology, Venereology and Leprology. 2014 Spt-Oct ; 80 (5): 402-408.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/154917
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2014;volume=80;issue=5;spage=402;epage=408;aulast=Patnaiken_US
dc.subjectBorderline leprosyen_US
dc.subjectdiagnosisen_US
dc.subjecthistologic variablesen_US
dc.subjectskin biopsiesen_US
dc.subjecttype 1 lepra reactionen_US
dc.subject.meshAdult
dc.subject.meshApoptosis
dc.subject.meshBiopsy
dc.subject.meshCase-Control Studies
dc.subject.meshEdema --pathology
dc.subject.meshFemale
dc.subject.meshGiant Cells --pathology
dc.subject.meshGranuloma --pathology
dc.subject.meshHumans
dc.subject.meshLeprosy, Borderline --pathology
dc.subject.meshMale
dc.subject.meshProspective Studies
dc.subject.meshSkin --pathology
dc.titleEvaluation of key histologic variables in skin biopsies of patients of borderline leprosy with type 1 lepra reaction.en_US
dc.typeArticleen_US
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