P-glycoprotein expression as a predictor of response to neoadjuvant chemotherapy in breast cancer.

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dc.contributor.authorVishnukumar, S
dc.contributor.authorUmamaheswaran, G
dc.contributor.authorAnichavezhi, D
dc.contributor.authorIndumathy, S
dc.contributor.authorAdithan, C
dc.contributor.authorSrinivasan, K
dc.contributor.authorKadambari, D
dc.date.accessioned2013-10-04T09:59:50Z
dc.date.available2013-10-04T09:59:50Z
dc.date.issued2013-07
dc.description.abstractBACKGROUND: Chemoresistance is an important factor determining the response of tumor to neoadjuvant chemotherapy (NACT). P-glycoprotein (P-gp) expression-mediated drug efflux is one of the mechanisms responsible for multi-drug resistance. Our study was aimed to determine the role of P-gp expression as a predictor of response to NACT in locally advanced breast cancer (LABC) patients. MATERIALS AND METHODS: P-gp expression was performed by real-time quantitative polymerase chain reaction [qRT-PCR] in 76 patients with LABC. Response to adriamycin-based regimen was assessed both clinically and with contrast enhanced computed tomography (CECT) scan before and after NACT. The significance of correlation between tumor and P-gp levels was determined with Chi-square test. RESULTS: Twenty-one had high and 55 had low P-gp expression. On analyzing P-gp expression with response by World Health Organization (WHO) criteria, statistical significance was obtained (P = 0.038). Similarly, assessment of P-gp expression with response by Response Evaluation in Solid Tumors (RECIST) criteria in 48 patients showed statistical significance (P = 0.0005). CONCLUSION: This study proves that P-gp expression is a determinant factor in predicting response to NACT. Finally, detection of P-gp expression status before initiation of chemotherapy can be used as a predictive marker for NACT response and will also aid in avoiding the toxic side effects of NACT in non-responders.en_US
dc.identifier.citationVishnukumar S, Umamaheswaran G, Anichavezhi D, Indumathy S, Adithan C, Srinivasan K, Kadambari D. P-glycoprotein expression as a predictor of response to neoadjuvant chemotherapy in breast cancer. Indian Journal of Cancer. 2013 July-Sept; 50(3): 195-199.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/148648
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2013;volume=50;issue=3;spage=195;epage=199;aulast=Vishnukumaren_US
dc.subjectBreast canceren_US
dc.subjectneoadjuvant chemotherapyen_US
dc.subjectP-glycoproteinen_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic use
dc.subject.meshBreast Neoplasms --drug therapy
dc.subject.meshBreast Neoplasms --metabolism
dc.subject.meshChemotherapy, Adjuvant
dc.subject.meshDrug Resistance, Neoplasm --physiology
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshNeoadjuvant Therapy --methods
dc.subject.meshP-Glycoprotein --biosynthesis
dc.subject.meshReal-Time Polymerase Chain Reaction
dc.subject.meshTumor Markers, Biological --analysis
dc.titleP-glycoprotein expression as a predictor of response to neoadjuvant chemotherapy in breast cancer.en_US
dc.typeArticleen_US
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