Study of Carotid Intima Media Thickness (CIMT) In Type 2 Diabetes Mellitus and Its Correlation with Glycaemic Control and Inflammatory Marker HsCRP

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dc.contributor.authorKumar, Ashoken_US
dc.contributor.authorRathore, Abhisheken_US
dc.contributor.authorSingh, Anupam Kumaren_US
dc.date.accessioned2020-09-24T07:26:42Z
dc.date.available2020-09-24T07:26:42Z
dc.date.issued2020-01
dc.description.abstractBackground: Carotid Intima Media Thickness (CIMT) andCRP (C Reactive Protein) are have been used for measuringAtherosclerotic Risk in Diabetics. However there is paucity ofdata regarding their importance in Statin Naïve Diabetics.Aim: To study Correlation of CIMT with glycaemic control andhsCRP in Statin Naïve Diabetics.Materials and Methods: 80 Cases (Patient suffering from type2 Diabetes Mellitus) and 20 controls (non- diabetic healthpatients) presenting in outpatient department of a tertiaryHospital were included in this observational cross sectionalobservational study. Complete Blood Count, urine Routine andMicroscopy, urine for microalbuminuria, fasting plasma glucose(FPG), postprandial plasma glucose (PPPG), glycatedhaemoglobin (HbA1C), lipid profile, renal function test, hs-CRPand CIMT were evaluated in each individual. Independentsamples T-test was used to compare CIMT and hs-CRP bothcases and controls. Test of proportion and chi-square test wasused for association between categorical variables.Spearman’s method was used to assess correlation betweenhsCRP and CIMT.Results: 80 cases (Statin naïve and Non-smoker Diabeticpatients and 20 healthy controls were included in this study.Average CIMT in cases was significantly higher in Diabeticcases than Control (0.66 + 0.14 vs 0.56±0.05, difference= 0.10 mm, 95% C.I. (0.1 - 0.17), p < 0.0001). HsCRP wassignificantly correlated with average CIMT in Diabetic cases.(r=0.512, 95% C.I. 0.33-0.658, p<0.0001). Fasting Blood Sugarwas correlated with average CIMT in Diabetic cases. (r=0.234,95% C.I. 0.015-0.432, p=0.0366). Post Prandial Blood Sugarwas also correlated with average CIMT (r=0.300, 95% C.I.0.086-0.488, p=0.00677).Conclusion: Cardiovascular risk factors like glycaemic controland inflammatory markers like hsCRP are significantlyassociated with CIMT even in non-smoking and statin naïveDiabetics.en_US
dc.identifier.affiliationsProfessor & Head, Dept. of Medicine, Santosh Medical College & Hospital, Ghaziabad, Uttar Pradesh, India.en_US
dc.identifier.affiliationsSenior Resident, Dept. of Medicine, IGESI Hospital, Jhilmil, New Delhi, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Dept. of Medicine, Santosh Medical College & Hospital, Ghaziabad, Uttar Pradesh, Indiaen_US
dc.identifier.citationKumar Ashok, Rathore Abhishek, Singh Anupam Kumar. Study of Carotid Intima Media Thickness (CIMT) In Type 2 Diabetes Mellitus and Its Correlation with Glycaemic Control and Inflammatory Marker HsCRP. International Journal of Medical Research Professionals. 2020 Jan; 6(1): 81-86en_US
dc.identifier.issn2454-6364
dc.identifier.issn2454-6356
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203525
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org//10..21276/ijmrp.2020.6.1.022en_US
dc.subjectCarotid Intima Media Thickness (CIMT)en_US
dc.subjectDiabetes Mellitusen_US
dc.subjectGlycaemic Controlen_US
dc.subjectHsCRPen_US
dc.titleStudy of Carotid Intima Media Thickness (CIMT) In Type 2 Diabetes Mellitus and Its Correlation with Glycaemic Control and Inflammatory Marker HsCRPen_US
dc.typeJournal Articleen_US
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