Gastroesophageal reflux disease in bronchial asthma and the response to omeprazole.

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dc.contributor.authorGopal, Bharaten_US
dc.contributor.authorSinghal, Pankajen_US
dc.contributor.authorGaur, S Nen_US
dc.date.accessioned2009-05-27T17:12:13Z
dc.date.available2009-05-27T17:12:13Z
dc.date.issued2005-03-07en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractThe objective of this study was to determine the incidence of gastroesophageal reflux disease (GERD) in bronchial asthma and the role of omeprazole for asthmatics with symptoms of GERD. Seventy asthmatics were screened for GERD by questionnaire. Patients with a history suggestive of GERD were confirmed by Bernstein test and further investigated for airway responsiveness to instillation of HCl in the esophagus. Symptom score, drug score and spirometric values were recorded initially and after four weeks of treatment with omeprazole. It was found that 74.28% of asthmatics had a history of GERD. Forty patients tested positive by Bernstein test and also showed airway responsiveness to instillation of HCl in the esophagus. There was a significant improvement in symptom scores (p < 0.001), drug scores (p < 0.001) and spirometric values (p < 0.001) after adding omeprazole to their treatment regimen. It was concluded that bronchial asthma and GERD are associated in the majority of patients (57.14%) and such patients are likely to improve with omeprazole.en_US
dc.description.affiliationDepartment of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi-110007, India.en_US
dc.identifier.citationGopal B, Singhal P, Gaur SN. Gastroesophageal reflux disease in bronchial asthma and the response to omeprazole. Asian Pacific Journal of Allergy and Immunology. 2005 Mar; 23(1): 29-34en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36677
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Ulcer Agents --therapeutic useen_US
dc.subject.meshAsthma --complicationsen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshGastroesophageal Reflux --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOmeprazole --therapeutic useen_US
dc.subject.meshSpirometryen_US
dc.titleGastroesophageal reflux disease in bronchial asthma and the response to omeprazole.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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