Variability in platelet response to a single daily dose of 150 mg enteric coated aspirin in a high risk population.

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dc.contributor.authorMardikar, Hen_US
dc.contributor.authorDeo, Den_US
dc.contributor.authorDeshpande, Nen_US
dc.contributor.authorMardikar, Manjushaen_US
dc.contributor.authorGhosh, Aen_US
dc.contributor.authorMunot, Khushbooen_US
dc.contributor.authorSteinhubl, Sen_US
dc.contributor.authorMukherjee, Den_US
dc.date.accessioned2008-05-15en_US
dc.date.accessioned2009-05-30T17:36:44Z
dc.date.available2008-05-15en_US
dc.date.available2009-05-30T17:36:44Z
dc.date.issued2008-05-15en_US
dc.description.abstractPURPOSE: Previous studies have reported inadequate anti-platelet effect in 0.4-35% of patients taking aspirin. Such studies have arbitrarily defined the terms "semi-responders", "non-responders" or "resistant" to variable doses of aspirin on the basis of absolute values derived from different ex-vivo platelet aggregation (PA) methods. Our objective was to define response to 150-mg dose of aspirin in terms of normally distributed values using an ex-vivo measure of PA in a population at high risk for vascular events. METHODS: We prospectively studied high risk patients with either established coronary artery disease (CAD) or stroke or transient ischemic attack (TIA) or peripheral vascular disease or with multiple atherothrombotic risk factors like diabetes plus one of the following-- hypertension, increased total cholesterol, cigarette smoking, micro-albuminuria, low-high density lipoprotein (HDL), family history of CAD and receiving single 150 mg dose of aspirin daily. PA was assessed by chronolog lumi-aggregometer (490-2D) using arachidonic acid (AA) reagent. RESULTS: 130 patients were studied. The response of subjects to aspirin followed a normal, bell shaped distribution curve with a mean and standard deviation (S.D.) of 13.1 +/- 4.4%. 3.1% patients had PA values more than 2 S.D. of the mean, hence termed as hypo-responders to aspirin while another 3.1% patients had PA values less than 2 S.D. of the mean, hence termed as hyper-responders to aspirin. CONCLUSION: There is minimal inter-individual variability in the response to aspirin when tested with AA as the reagent. The response to aspirin follows a normal Gaussian distribution. The prevalence of hypo-responders to aspirin in high risk population is only 3.1%. This is the first study to document "hypo" and "hyper-responders" to single daily dose of 150 mg aspirin. The clinical relevance of these findings remains to be determined.en_US
dc.description.affiliationSpandan Heart Institute and Research Center, Nagpur, India.en_US
dc.identifier.citationMardikar H, Deo D, Deshpande N, Mardikar M, Ghosh A, Munot K, Steinhubl S, Mukherjee D. Variability in platelet response to a single daily dose of 150 mg enteric coated aspirin in a high risk population. Journal of the Association of Physicians of India. 2008 May; 56(): 321-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/85053
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAgeden_US
dc.subject.meshAspirin --administration & dosageen_US
dc.subject.meshBleeding Time --statistics & numerical dataen_US
dc.subject.meshCardiovascular Diseases --prevention & controlen_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNormal Distributionen_US
dc.subject.meshPlatelet Aggregation --drug effectsen_US
dc.subject.meshPlatelet Aggregation Inhibitors --administration & dosageen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTablets, Enteric-Coateden_US
dc.titleVariability in platelet response to a single daily dose of 150 mg enteric coated aspirin in a high risk population.en_US
dc.typeJournal Articleen_US
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