Basic requirements to establish a neuromuscular laboratory

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dc.contributor.authorNandeesh, BNen_US
dc.contributor.authorNarayanappa, Gen_US
dc.contributor.authorYasha, T C.en_US
dc.date.accessioned2023-08-10T07:32:36Z
dc.date.available2023-08-10T07:32:36Z
dc.date.issued2022-05
dc.description.abstractHistopathological analysis of muscle biopsy is a prerequisite in the evaluation of neuromuscular disorders, particularly inflammatory myopathies, metabolic myopathies, congenital myopathies, muscular dystrophies and differentiating myopathies and neurogenic disorders with overlapping clinically features. It not only provides useful information that helps in the diagnosis but also treatment and management. Fundamental skills and basic knowledge regarding handling, processing and analyzing a muscle biopsy are required in any specialized or a general pathology lab supporting neuromuscular clinical services. Care during transport of the muscle biopsy, sample receipt in the laboratory and grossing is very important. Standard operating procedure should be followed for the preanalytical steps (freezing and cryomicrotomy), routine and special staining (enzyme and non enzymatic) and immunohistochemistry. A well organized neuromuscular laboratory with good quality management system is necessary for the practice of myopathology. This article gives an overview of establishing such a laboratory.en_US
dc.identifier.affiliationsDepartment of Neuropathology, NIMHANS, Bangalore, Karnataka, Indiaen_US
dc.identifier.citationNandeesh BN, Narayanappa G, Yasha T C.. Basic requirements to establish a neuromuscular laboratory. Indian Journal of Pathology & Microbiology. 2022 May; 65(1): 233-240en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223285
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume65en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_7_22en_US
dc.subjectCryomicrotomyen_US
dc.subjectenzyme histochemistryen_US
dc.subjectmuscle biopsyen_US
dc.subjectmyopathologyen_US
dc.subjectsnap-freezingen_US
dc.titleBasic requirements to establish a neuromuscular laboratoryen_US
dc.typeJournal Articleen_US
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