Hypotension is a predictor of mortality in acute exacerbations of chronic obstructive pulmonary disease.

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dc.contributor.authorChandra, Divayen_US
dc.contributor.authorGuntupalli, Kalpalatha Ken_US
dc.contributor.authorGuleria, Randeepen_US
dc.date.accessioned2007-01-30en_US
dc.date.accessioned2009-05-27T10:31:08Z
dc.date.available2007-01-30en_US
dc.date.available2009-05-27T10:31:08Z
dc.date.issued2007-01-30en_US
dc.description.abstractOBJECTIVES: To identify variables that predict the in-hospital course and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). METHODS: A retrospective analysis of 94 patients (20 females) with AECOPD. Twenty-one variables including arterial blood gas studies were analysed. RESULTS: The mean age was 61.2 years. The in-hospital mortality rate was 12.8%; 28.6% of patients required invasive mechanical ventilation and 37.2% required ICU care. In univariate analysis, aypotension at presentation (systolic blood-pressure < 90 mmHg) [p = 0.002, odds ratio OR 10.95, 95% confidence interval (CI) 1.90-63.00); central cyanosis (p = 0.007, OR 6.91, 95% CI 1.42-33.59); and cor-pulmonale (p = 0.009, OR 10.46, 95% CI 1.26-86.46) were univariately associated with in-hospital mortality. On multivariate analysis, hypotension (p = 0.049, OR 18.419, 95% CI 1.013-334.752) remained the only independent predictor. CONCLUSIONS: More than the markers of poor gas exchange, the presence of hypotension indicates a poor in-hospital prognosis in AECOPD.en_US
dc.description.affiliationDepartment of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India. divayc@bcm.tmc.eduen_US
dc.identifier.citationChandra D, Guntupalli KK, Guleria R. Hypotension is a predictor of mortality in acute exacerbations of chronic obstructive pulmonary disease. The Indian Journal of Chest Diseases & Allied Sciences. 2007 Jan-Mar; 49(1): 13-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30262
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/iae/iaem.shtmlen_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshHospital Mortalityen_US
dc.subject.meshHumansen_US
dc.subject.meshHypotension --complicationsen_US
dc.subject.meshIndiaen_US
dc.subject.meshIntensive Careen_US
dc.subject.meshLength of Stayen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulmonary Disease, Chronic Obstructive --complicationsen_US
dc.subject.meshRespiration, Artificialen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleHypotension is a predictor of mortality in acute exacerbations of chronic obstructive pulmonary disease.en_US
dc.typeJournal Articleen_US
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