Antiviral efficacy of adefovir dipivoxil in the treatment of chronic hepatitis B subjects from Indian subcontinent.

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dc.contributor.authorIsmail, A M
dc.contributor.authorRamachandran, J
dc.contributor.authorKannangai, R
dc.contributor.authorAbraham, P
dc.date.accessioned2015-03-14T10:01:57Z
dc.date.available2015-03-14T10:01:57Z
dc.date.issued2014-01
dc.description.abstractAdefovir is one of the therapeutic options for the treatment of chronic hepatitis B. A total of 30 adefovir-experienced subjects with the median treatment duration of 12 (interquartile range (IQR) 6-18) months were studied. Virological response was measured by hepatitis B virus deoxyribonucleic acid (HBV DNA) levels. HBV reverse transcriptase (rt) domains were sequenced for the identifi cation of resistance mutations. Among the 30 subjects, two (7%) showed virological response and 19 (63%) were non-responders. The virological response for the remaining nine (30%) subjects was not determined. On sequence analysis, two subjects were identifi ed with rtI169L and rtA181V mutation after 9 months and 18 months of adefovir treatment, respectively. Though the frequencies of adefovir resistance mutations are low, a large majority of subjects showed non-response. Therefore, adefovir in the management of HBV should be used judiciously.en_US
dc.identifier.citationIsmail A M, Ramachandran J, Kannangai R, Abraham P. Antiviral efficacy of adefovir dipivoxil in the treatment of chronic hepatitis B subjects from Indian subcontinent. Indian Journal of Medical Microbiology. 2014 Jan- Mar ; 32 (1): 60-63.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/156851
dc.language.isoenen_US
dc.source.urihttps://www.ijmm.org/article.asp?issn=0255-0857;year=2014;volume=32;issue=1;spage=60;epage=63;aulast=Ismailen_US
dc.subjectAdefoviren_US
dc.subjectchronic hepatitis Ben_US
dc.subjectdrug resistanceen_US
dc.subjecthepatitis B virusen_US
dc.titleAntiviral efficacy of adefovir dipivoxil in the treatment of chronic hepatitis B subjects from Indian subcontinent.en_US
dc.typeArticleen_US
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